OHSU-PSU School of Public Health, Portland, OR 97239, USA.
Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, USA.
Int J Environ Res Public Health. 2021 Mar 20;18(6):3230. doi: 10.3390/ijerph18063230.
The purpose of this study is to examine associations between objectively measured workplace sedentary behavior and physiological markers of health. We hypothesize that increased sedentary time and more frequent bouts of uninterrupted sitting are associated with increased hemoglobin A1c, increased blood pressure, and impaired endothelial function. Call center employees (N = 241) were enrolled from four worksites in the United States. Participants completed a survey and a physical health assessment. Sedentary behavior and sitting/standing time at work were quantified using an accelerometer. Hemoglobin A1c was measured using a finger-prick and portable analyzer. Blood pressure was measured with an automated cuff, and vascular endothelial function was assessed in a subsample of participants (n = 56) using EndoPAT. We analyzed data with two series of ordinary least squares regressions, first to examine relationships between bouts of uninterrupted sitting and physiological outcomes, and second to examine relationships between physical activity and sitting/standing time at work and physiological outcomes. The sample was primarily female, and on average was obese, prehypertensive, and prediabetic. There were no significant relationships between bouts of uninterrupted sitting or physical activity/sitting/standing time at work and physiological outcomes. In a sample that is predominantly sedentary, at risk for cardiovascular disease, and prediabetic, there are no significant associations between workplace sedentary behavior and physiological markers. The lack of associations could be related to either physiological adaptations or ceiling effects in this sample.
本研究旨在探讨工作场所中客观测量的久坐行为与健康生理标志物之间的关联。我们假设，久坐时间的增加和更频繁的无间断久坐与糖化血红蛋白升高、血压升高和内皮功能受损有关。从美国的四个工作场所招募了 241 名呼叫中心员工作为参与者。参与者完成了一项调查和一项身体健康评估。使用加速度计来量化久坐行为和工作时的坐/站时间。使用指尖和便携式分析仪测量糖化血红蛋白。使用自动袖带测量血压，并且在参与者的亚组（n=56）中使用 EndoPAT 评估血管内皮功能。我们使用两系列普通最小二乘法回归分析数据，首先是检验无间断久坐时间与生理结果之间的关系，其次是检验体力活动与工作时的坐/站时间与生理结果之间的关系。该样本主要是女性，平均肥胖、血压偏高且患有前驱糖尿病。无间断久坐时间或体力活动/坐站时间与生理结果之间没有显著关系。在一个主要是久坐、有心血管疾病风险和前驱糖尿病的样本中，工作场所久坐行为与生理标志物之间没有显著关联。这种关联的缺乏可能与该样本中的生理适应或上限效应有关。
