Sartoretti Julie, Eberhardt Christiane S
Center for Vaccinology, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, 1211 Geneva 4, Switzerland.
Department of Woman, Child and Adolescent Medicine, Geneva University Hospitals and Faculty of Medicine, 6 rue Willy-Donze, 1211 Geneve 4, Switzerland.
Vaccines (Basel). 2021 Mar 24;9(4):306. doi: 10.3390/vaccines9040306.
Early life immunity is a complex field of research and there are still gaps in knowledge regarding the detailed mechanism of maternal antibody transfer, the impact of maternal antibodies on infant vaccine responses and the ontogeny of human early life immunity. A comprehensive understanding is necessary to identify requirements for early life vaccines and to improve early childhood immunization. New immunological methods have facilitated performing research in the youngest, however, some questions can only be addressed in animal models. To date, mostly murine models are used to study neonatal and infant immunity since they are well-described, easy to use and cost effective. Given their limitations especially in the transfer biology of maternal antibodies and the lack of infectivity of numerous human pathogens, this opinion piece discusses the potential and prerequisites of the nonhuman primate model in studying early life immunity and maternal antibody transfer.
早期生命免疫是一个复杂的研究领域，在母体抗体转移的详细机制、母体抗体对婴儿疫苗反应的影响以及人类早期生命免疫的个体发生等方面，仍存在知识空白。全面了解这些内容对于确定早期生命疫苗的需求以及改善幼儿免疫接种至关重要。新的免疫学方法有助于在最年幼的个体中开展研究，然而，一些问题只能在动物模型中解决。迄今为止，大多使用小鼠模型来研究新生儿和婴儿免疫，因为它们描述详尽、易于使用且成本效益高。鉴于其局限性，尤其是在母体抗体的转移生物学方面，以及许多人类病原体缺乏感染性，这篇观点文章讨论了非人类灵长类动物模型在研究早期生命免疫和母体抗体转移方面的潜力和前提条件。
