Siegrist C A, Lambert P H
WHO Collaborating Centre for Neonatal Vaccinology, Geneva, Switzerland.
Dev Biol Stand. 1998;95:133-9.
The presence of maternally-derived antibodies at the time of immunization is known to interfere frequently with active immunization, with variable levels of clinical significance. Deciphering the rules as the basis of such inhibitory effects on infant vaccine responses would certainly contribute to the development of vaccination strategies for early life. These questions were addressed in murine neonatal or early life immunization models using various antigens (measles, tetanus, RSV) and antigen-presentation systems (peptides, proteins, live attenuated vaccines, live recombinant vectors or DNA plasmids) in the absence or presence of maternal antibodies. Factors identified as crucial determinants of maternal antibody-mediated effects on both live and non-live vaccines include the relative amount of maternal antibodies and of vaccine antigens present at immunization, antigenic conformation, epitope specificity and the distinct influence on B-cell and T-cell vaccine responses.
已知免疫时母源抗体的存在常常会干扰主动免疫，其临床意义程度不一。解读这些对婴儿疫苗反应产生抑制作用的规则，无疑将有助于制定早期生命阶段的疫苗接种策略。在小鼠新生期或生命早期免疫模型中，使用各种抗原（麻疹、破伤风、呼吸道合胞病毒）和抗原呈递系统（肽、蛋白质、减毒活疫苗、重组活载体或DNA质粒），在有或无母源抗体的情况下研究了这些问题。被确定为母源抗体对活疫苗和非活疫苗介导作用关键决定因素的有：免疫时母源抗体和疫苗抗原的相对量、抗原构象、表位特异性以及对B细胞和T细胞疫苗反应的不同影响。
