Villa Carla, Russo Eleonora
Section of Medicinal and Cosmetic Chemistry, Department of Pharmacy, University of Genova, Viale Benedetto XV, 3-16132 Genova, Italy.
Materials (Basel). 2021 Mar 24;14(7):1577. doi: 10.3390/ma14071577.
Hand hygiene can be considered a strategic key useful in the containment of infections such as COVID-19 both at home and in communities because it can dramatically reduce the widespread outbreak of infections. In case of the unavailability of soap and water, "instant" hand sanitizers are recommended because their application can be considered easy, versatile, quick and often less aggressive for the skin. For these reasons, alcoholic and alcohol-free hand rub gels can be considered the best performing formulations on the market. Together with disinfectants and antiseptic agents, hydrogels play a fundamental role in obtaining stable formulations and are easy to disperse, with a pleasant skin feel and an overall good performance. Several compounds commonly used in the pharmaceutical, cosmetic and food industry are available for this purpose, in particular, cellulose derivatives and synthetic polymers derivatives. Each of them is available in several grades, presenting different thickening behavior, rheological properties and compatibility with other ingredients, alcohols in particular. For all these reasons, it is important to explore hydrogel properties and behaviors in different contexts (i.e., hydroalcoholic and aqueous media) in order to develop new and performing hand rub gels, always taking into account the different international legal frameworks regarding disinfectant and sanitizing formulations.
手部卫生可被视为在家中和社区控制 COVID-19 等感染的一项关键战略措施，因为它能显著减少感染的广泛传播。在没有肥皂和水的情况下，建议使用“即时”洗手液，因为其使用简便、用途广泛、速度快，且通常对皮肤刺激性较小。基于这些原因，含酒精和不含酒精的手部擦涂凝胶可被视为市场上性能最佳的配方产品。与消毒剂和防腐剂一起，水凝胶在获得稳定配方方面发挥着重要作用，且易于分散，具有宜人的肤感和总体良好的性能。为此，制药、化妆品和食品行业常用的几种化合物可供选用，特别是纤维素衍生物和合成聚合物衍生物。它们各自有多个等级，呈现出不同的增稠行为、流变特性以及与其他成分（尤其是酒精）的兼容性。出于所有这些原因，探索水凝胶在不同环境（即水醇介质和水性介质）中的特性和行为，以开发新的高性能手部擦涂凝胶非常重要，同时始终要考虑到关于消毒剂和卫生配方的不同国际法律框架。
