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具有伤口监测与治疗功能的水凝胶敷料研究进展

Progress of Hydrogel Dressings with Wound Monitoring and Treatment Functions.

作者信息

Jin Shanshan, Newton Md All Amin, Cheng Hongju, Zhang Qinchen, Gao Weihong, Zheng Yuansheng, Lu Zan, Dai Zijian, Zhu Jie

机构信息

School of Textiles and Fashion, Shanghai University of Engineering Science, Shanghai 201620, China.

Innovation Center for Textile Science and Technology, Donghua University, Shanghai 200051, China.

出版信息

Gels. 2023 Aug 28;9(9):694. doi: 10.3390/gels9090694.

DOI:10.3390/gels9090694
PMID:37754375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10528853/
Abstract

Hydrogels are widely used in wound dressings due to their moisturizing properties and biocompatibility. However, traditional hydrogel dressings cannot monitor wounds and provide accurate treatment. Recent advancements focus on hydrogel dressings with integrated monitoring and treatment functions, using sensors or intelligent materials to detect changes in the wound microenvironment. These dressings enable responsive treatment to promote wound healing. They can carry out responsive dynamic treatment in time to effectively promote wound healing. However, there is still a lack of comprehensive reviews of hydrogel wound dressings that incorporate both wound micro-environment monitoring and treatment functions. Therefore, this review categorizes hydrogel dressings according to wound types and examines their current status, progress, challenges, and future trends. It discusses various wound types, including infected wounds, burns, and diabetic and pressure ulcers, and explores the wound healing process. The review presents hydrogel dressings that monitor wound conditions and provide tailored treatment, such as pH-sensitive, temperature-sensitive, glucose-sensitive, pressure-sensitive, and nano-composite hydrogel dressings. Challenges include developing dressings that meet the standards of excellent biocompatibility, improving monitoring accuracy and sensitivity, and overcoming obstacles to production and commercialization. Furthermore, it provides the current status, progress, challenges, and future trends in this field, aiming to give a clear view of its past, present, and future.

摘要

水凝胶因其保湿性能和生物相容性而被广泛应用于伤口敷料。然而，传统的水凝胶敷料无法监测伤口并提供准确的治疗。最近的进展集中在具有集成监测和治疗功能的水凝胶敷料上，利用传感器或智能材料来检测伤口微环境的变化。这些敷料能够进行响应式治疗以促进伤口愈合。它们可以及时进行响应式动态治疗，有效促进伤口愈合。然而，对于结合伤口微环境监测和治疗功能的水凝胶伤口敷料，仍然缺乏全面的综述。因此，本综述根据伤口类型对水凝胶敷料进行分类，并考察它们的现状、进展、挑战和未来趋势。它讨论了各种伤口类型，包括感染伤口、烧伤以及糖尿病性溃疡和压疮，并探讨了伤口愈合过程。该综述介绍了能够监测伤口状况并提供定制治疗的水凝胶敷料，如对pH敏感、对温度敏感、对葡萄糖敏感、对压力敏感的水凝胶敷料以及纳米复合水凝胶敷料。挑战包括开发符合优异生物相容性标准的敷料、提高监测的准确性和灵敏度，以及克服生产和商业化方面的障碍。此外，它还提供了该领域的现状、进展、挑战和未来趋势，旨在清晰呈现其过去、现在和未来。

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