血管生成在非酒精性脂肪性肝病发病机制中的作用。
Role of Angiogenesis in the Pathogenesis of NAFLD.
作者信息
Lei Lin, Ei Mourabit Haquima, Housset Chantal, Cadoret Axelle, Lemoinne Sara
机构信息
Centre de Recherche Saint-Antoine (CRSA) and Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne Université, INSERM, 75012 Paris, France.
Department of Hepatology, Reference Center for Inflammatory Biliary Diseases and Autoimmune Hepatitis (CRMR, MIVB-H), Assistance Publique-Hôpitaux de Paris (AP-HP), Saint-Antoine Hospital, 75012 Paris, France.
出版信息
J Clin Med. 2021 Mar 24;10(7):1338. doi: 10.3390/jcm10071338.
Non-alcoholic fatty liver disease (NAFLD) has become the leading cause of chronic liver disease, exposing to the risk of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Angio-genesis is a complex process leading to the development of new vessels from pre-existing vessels. Angiogenesis is triggered by hypoxia and inflammation and is driven by the action of proangiogenic cytokines, mainly vascular endothelial growth factor (VEGF). In this review, we focus on liver angiogenesis associated with NAFLD and analyze the evidence of liver angiogenesis in animal models of NAFLD and in NAFLD patients. We also report the data explaining the role of angiogenesis in the progression of NAFLD and discuss the potential of targeting angiogenesis, notably VEGF, to treat NAFLD.
非酒精性脂肪性肝病（NAFLD）已成为慢性肝病的主要病因，面临肝纤维化、肝硬化和肝细胞癌（HCC）的风险。血管生成是一个复杂的过程，导致从现有血管发育出新的血管。血管生成由缺氧和炎症触发，并由促血管生成细胞因子的作用驱动，主要是血管内皮生长因子（VEGF）。在本综述中，我们聚焦于与NAFLD相关的肝脏血管生成，并分析NAFLD动物模型和NAFLD患者中肝脏血管生成的证据。我们还报告了解释血管生成在NAFLD进展中作用的数据，并讨论了靶向血管生成（尤其是VEGF）治疗NAFLD的潜力。
Zotero 插件