Paleari Laura, Pesce Silvia, Rutigliani Mariangela, Greppi Marco, Obino Valentina, Gorlero Franco, Vellone Valerio Gaetano, Marcenaro Emanuela
A.Li.Sa., Liguria Region Health Authority, 16121 Genoa, Italy.
Department of Experimental Medicine and Centre of Excellence for Biomedical Research, University of Genoa, 16132 Genoa, Italy.
Cancers (Basel). 2021 Mar 24;13(7):1496. doi: 10.3390/cancers13071496.
EC is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors, such as aging and obesity, tends to become a public health issue. Although EC is a hormone-dependent neoplasm, there are no recommendations for the determination of steroid hormone receptors in the tumor tissue and no hormone therapy has ever been assessed in the adjuvant setting. Furthermore, its immune environment has been slightly characterized, but recent evidences point out how EC microenvironment may increase self-tolerance by reducing the recruitment of cytotoxic immune cells to the tumor site and/or modifying their phenotype, making these cells no longer able to suppress tumor growth. Here we highlight insights for EC management from diagnosis to a desirable trend of personalized treatment.
子宫内膜癌是发达国家女性生殖道最常见的癌症，由于诸如老龄化和肥胖等风险因素导致其发病率不断上升，它正逐渐成为一个公共卫生问题。尽管子宫内膜癌是一种激素依赖性肿瘤，但对于肿瘤组织中类固醇激素受体的测定尚无推荐方法，且从未在辅助治疗中评估过激素疗法。此外，其免疫环境的特征尚不明确，但最近的证据指出，子宫内膜癌的微环境可能通过减少细胞毒性免疫细胞向肿瘤部位的募集和/或改变其表型来增强自身耐受性，使这些细胞不再能够抑制肿瘤生长。在此，我们着重介绍从诊断到理想的个性化治疗趋势等方面有关子宫内膜癌管理的见解。
