UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie Respiratoire Intégrative, CESP, Université Paris-Saclay, 94807 Villejuif, France.
MGEN Foundation for Public Health (FESP-MGEN), 75748 Paris, France.
Int J Environ Res Public Health. 2021 Mar 24;18(7):3366. doi: 10.3390/ijerph18073366.
Household disinfectant and cleaning products (HDCPs) assessment is challenging in epidemiological research. We hypothesized that a newly-developed smartphone application was more objective than questionnaires in assessing HDCPs. Therefore, we aimed to compare both methods, in terms of exposure assessments and respiratory health effects estimates. The women of the SEPAGES birth cohort completed repeated validated questionnaires on HDCPs and respiratory health and used an application to report HDCPs and scan products barcodes, subsequently linked with an ingredients database. Agreements between the two methods were assessed by Kappa coefficients. Logistic regression models estimated associations of HDCP with asthma symptom score. The 101 participants (18 with asthma symptom score ≥1) scanned 617 different products (580 with available ingredients list). Slight to fair agreements for sprays, bleach and scented HDCP were observed (Kappa: 0.35, 0.25, 0.11, respectively). Strength of the associations between HDCP and asthma symptom score varied between both methods but all odds ratios (OR) were greater than one. The number of scanned products used weekly was significantly associated with the asthma symptom score (adjusted-OR [CI 95%]: 1.15 [1.00-1.32]). This study shows the importance of using novel tools in epidemiological research to objectively assess HDCP and therefore reduce exposure measurement errors.
家庭消毒剂和清洁产品(HDCPs)评估在流行病学研究中具有挑战性。我们假设新开发的智能手机应用程序在评估 HDCPs 方面比问卷更客观。因此,我们旨在比较这两种方法,评估暴露评估和呼吸健康影响的估计。SEPAGES 出生队列的女性反复完成关于 HDCPs 和呼吸健康的经过验证的问卷,并使用应用程序报告 HDCPs 并扫描产品条形码,随后与成分数据库相关联。两种方法之间的一致性通过 Kappa 系数进行评估。逻辑回归模型估计了 HDCP 与哮喘症状评分的关联。101 名参与者(18 名哮喘症状评分≥1)扫描了 617 种不同的产品(580 种有可用成分清单)。对于喷雾剂、漂白剂和有香味的 HDCP,观察到轻微到适度的一致性(Kappa:0.35、0.25、0.11,分别)。两种方法之间 HDCP 和哮喘症状评分之间的关联强度不同,但所有比值比(OR)均大于 1。每周扫描的产品数量与哮喘症状评分显著相关(调整后的 OR [95%CI]:1.15 [1.00-1.32])。本研究表明,在流行病学研究中使用新工具客观评估 HDCP 以减少暴露测量误差的重要性。