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关于带状疱疹相关疼痛及带状疱疹后神经痛的管理。

Concerning the management of pain associated with herpes zoster and of postherpetic neuralgia.

作者信息

King Robert B

机构信息

Department of Neurological Surgery, SUNY Health Science Center, Syracuse, NY 13210 U.S.A.

出版信息

Pain. 1988 Apr;33(1):73-78. doi: 10.1016/0304-3959(88)90206-0.

Abstract

This simple method of achieving substantial pain control in patients with documented herpes zoster and postherpetic neuralgia has been effective in each of the patients in whom it has been used (the most recent 12 cases have been summarized for this report). It has been more effective than narcotic analgesics, oral anti-inflammatory analgesics, sedatives, tranquilizers, TENS, hypnosis and the wide variety of operative measures we have tried in the past. Although it was initially used pragmatically, there is now a reasonable rationale for its effectiveness that can be proposed based on more recent insights into the anatomy and neurophysiology of cutaneous nociceptors and the neuropharmacology of aspirin. In view of the widely held persuasion that the management of pain syndromes associated with herpes zoster (especially severe postherpetic neuralgia) is an unsatisfactory and frustrating venture, it seemed reasonable to report these more favorable clinical observations.

摘要

这种在确诊为带状疱疹和带状疱疹后神经痛的患者中实现显著疼痛控制的简单方法,在每一位使用过该方法的患者身上都取得了成效(本报告总结了最近的12例病例)。它比麻醉性镇痛药、口服抗炎镇痛药、镇静剂、 tranquilizers(原文此处拼写有误,推测可能是tranquillizers,即安定药)、经皮神经电刺激疗法(TENS)、催眠以及我们过去尝试过的各种手术措施都更有效。尽管它最初是在实用的基础上使用的,但现在基于对皮肤伤害感受器的解剖学和神经生理学以及阿司匹林的神经药理学的最新认识,可以为其有效性提出合理的理论依据。鉴于人们普遍认为与带状疱疹相关的疼痛综合征(尤其是严重的带状疱疹后神经痛)的治疗是一项不尽人意且令人沮丧的工作,报告这些更有利的临床观察结果似乎是合理的。

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