Coderre Terence J, Wall Patrick D
Cerebral Functions Research Group, Department of Anatomy and Developmental Neurobiology, University College London, London WC1E 6BT U.K.
Pain. 1988 Apr;33(1):81-85. doi: 10.1016/0304-3959(88)90208-4.
Ankle joint urate arthritis in rats is associated with increased responses to ankle stimulation and decreased responses to stimulation of the distal foot. To determine the influence of the forebrain on flexion reflexes in this model, responses to ankle and foot stimulation were examined in chronic decerebrate rats, decerebrated either before or after the induction of the arthritis. The increased responsiveness to stimulation of the arthritic ankle which had been observed after 24 h of urate arthritis was equally apparent in animals decerebrated 24 h before the induction of the arthritis and in those decerebrated 24 h after the urate injection. However, the decreased responsiveness of the distal foot to pressure or temperature stimuli, which had been observed in arthritic animals with an intact forebrain, was still apparent in animals decerebrated 24 h after the induction of the arthritis but did not appear in animals who had been decerebrated before the arthritis induction. It is concluded that the forebrain is required for the production of the reduced responsiveness of the distal foot but is not required for its maintenance once the insensitive state has been acquired.
大鼠踝关节尿酸盐性关节炎与踝关节刺激反应增强及足远端刺激反应减弱有关。为了确定前脑对该模型中屈肌反射的影响，我们在慢性去大脑大鼠中检测了对踝关节和足部刺激的反应，这些大鼠在关节炎诱导之前或之后进行去大脑处理。在尿酸盐性关节炎诱导24小时后观察到的对关节炎踝关节刺激反应性增加，在关节炎诱导前24小时去大脑的动物和尿酸盐注射后24小时去大脑的动物中同样明显。然而，在具有完整前脑的关节炎动物中观察到的足远端对压力或温度刺激反应性降低，在关节炎诱导后24小时去大脑的动物中仍然明显，但在关节炎诱导前就已去大脑的动物中未出现。结论是，前脑是产生足远端反应性降低所必需的，但一旦获得不敏感状态，维持该状态则不需要前脑。
