Pahk Kisoo, Kim Eung Ju, Kwon Hyun Woo, Joung Chanmin, Seo Hong Seog, Kim Sungeun
Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 02841, Korea.
Department of Cardiovascular Center, Korea University Guro Hospital, Seoul 08308, Korea.
Diagnostics (Basel). 2021 Mar 13;11(3):511. doi: 10.3390/diagnostics11030511.
Inflamed skeletal muscle promotes chronic inflammation in atherosclerotic plaques, thereby contributing to the increased risk of coronary artery disease (CAD). In this study, we evaluated the metabolic activity of psoas muscle, using F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), and its association with carotid artery inflammation and acute myocardial infarction (AMI). In total, 90 participants (32 AMI, 33 chronic stable angina (CSA), and 25 control) were enrolled in this prospective study. Metabolic activity of skeletal muscle (SM) was measured by using maximum standardized uptake value (SUVmax) of psoas muscle, and corresponding psoas muscle area (SM area) was also measured. Carotid artery inflammation was evaluated by using the target-to background ratio (TBR) of carotid artery. SM SUVmax was highest in AMI, intermediate in CSA, and lowest in control group. SM SUVmax was significantly correlated with carotid artery TBR and systemic inflammatory surrogate markers. Furthermore, SM SUVmax was independently associated with carotid artery TBR and showed better predictability than SM area for the prediction of AMI. Metabolic activity of psoas muscle assessed by F-FDG PET/CT was associated with coronary plaque vulnerability and synchronized with the carotid artery inflammation in the participants with CAD. Furthermore, it may also be useful to predict AMI.
炎症性骨骼肌会促进动脉粥样硬化斑块中的慢性炎症，从而增加冠状动脉疾病（CAD）的风险。在本研究中，我们使用F-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）评估了腰大肌的代谢活性，及其与颈动脉炎症和急性心肌梗死（AMI）的关联。共有90名参与者（32例AMI、33例慢性稳定型心绞痛（CSA）和25例对照）纳入了这项前瞻性研究。通过使用腰大肌的最大标准化摄取值（SUVmax）来测量骨骼肌（SM）的代谢活性，并测量相应的腰大肌面积（SM面积）。通过使用颈动脉的靶本比（TBR）来评估颈动脉炎症。SM SUVmax在AMI组中最高，在CSA组中居中，在对照组中最低。SM SUVmax与颈动脉TBR和全身炎症替代标志物显著相关。此外，SM SUVmax与颈动脉TBR独立相关，并且在预测AMI方面比SM面积具有更好的预测性。通过F-FDG PET/CT评估的腰大肌代谢活性与CAD参与者的冠状动脉斑块易损性相关，并与颈动脉炎症同步。此外，它可能对预测AMI也有用处。
