Department of Nuclear Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
Cardiovascular Center, Korea University Guro Hospital, Seoul, Republic of Korea.
PLoS One. 2020 Feb 6;15(2):e0228602. doi: 10.1371/journal.pone.0228602. eCollection 2020.
The inflammatory activity of visceral adipose tissue (VAT) is elevated in metabolic syndrome (MS), and associated with vulnerability to atherosclerosis. Inflammation can be assessed by glucose uptake in atherosclerotic plaques. We investigated whether the glucose uptake of VAT, assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), is associated with systemic inflammatory status, and related to the number of MS components.
18F-FDG PET/CT was performed in a total of 203 participants: 59 without MS component; M(0), 92 with one or two MS components; M(1-2), and 52 with MS. Glucose uptake in VAT was evaluated using the mean standardized uptake value (SUVmean) and the maximum SUV (SUVmax). Glucose uptakes of immune-related organs such as the spleen and bone marrow (BM) were evaluated using the SUVmax.
VAT SUVmax correlated with high-sensitivity C-reactive protein (hsCRP) and the SUVmax of spleen and BM, which reflect the status of systemic inflammation. Both hsCRP and the SUVmax of the spleen and BM were higher in the MS group than in the M(1-2) or M(0) groups. In VAT, SUVmax increased with increasing number of MS components, while SUVmean decreased.
The SUVmax and SUVmean of VAT assessed by 18F-FDG PET/CT reflected inflammation-driven unique glucose metabolism in the VAT of MS patients, distinct from that of atherosclerotic plaques.
代谢综合征（MS）患者内脏脂肪组织（VAT）的炎症活性升高，并与动脉粥样硬化易感性相关。炎症可通过动脉粥样硬化斑块中的葡萄糖摄取来评估。我们研究了 VAT 的葡萄糖摄取，通过 18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）评估，是否与全身炎症状态相关，以及与 MS 成分的数量相关。
共对 203 名参与者进行了 18F-FDG PET/CT 检查：59 名无 MS 成分；M(0)，92 名有一个或两个 MS 成分；M(1-2)，52 名 MS。使用平均标准化摄取值（SUVmean）和最大 SUV（SUVmax）评估 VAT 的葡萄糖摄取。使用 SUVmax 评估免疫相关器官（如脾脏和骨髓（BM）的葡萄糖摄取。
VAT SUVmax 与高敏 C 反应蛋白（hsCRP）以及脾脏和 BM 的 SUVmax 相关，这些反映了全身炎症状态。MS 组的 hsCRP 和脾脏及 BM 的 SUVmax 均高于 M(1-2)或 M(0)组。在 VAT 中，SUVmax 随 MS 成分数量的增加而增加，而 SUVmean 则降低。
18F-FDG PET/CT 评估的 VAT 的 SUVmax 和 SUVmean 反映了 MS 患者 VAT 中炎症驱动的独特葡萄糖代谢，与动脉粥样硬化斑块不同。
