Hageman J R, Holmes D, Suchy S, Hunt C E
Department of Pediatrics, Evanston Hospital, Illinois.
Pediatr Pulmonol. 1988;4(2):78-83. doi: 10.1002/ppul.1950040204.
Pneumogram (PG) recordings were performed in 87 very low birthweight (VLBW) asymptomatic infants just prior to hospital discharge to determine the relationships between: 1) a prior history of apnea of prematurity (AOP) and cardiorespiratory pattern; and 2) cardiorespiratory pattern at hospital discharge and postconceptional age. Apnea density (A6/D%) and longest apnea were significantly greater in those with (n = 66), versus without (n = 21) a prior history of AOP (P less than 0.05 and P less than 0.01, respectively). Although PG values for the 21 VLBW infants without a prior history of AOP did not differ significantly from those of full-term infants, for the 66 VLBW infants with a prior AOP history A6/D% (P less than 0.01), episodes of periodic breathing (P less than 0.05) and longest apnea (P less than 0.001) were significantly greater compared with full-term infants. Postconceptional age was significantly less in the VLBW infants with A6/D% values above, compared with those within the 95th percentile for normal infants (median age, 36 and 37.5 weeks; P = 0.01). Therefore, respiratory pattern abnormalities in asymptomatic VLBW infants ready for hospital discharge are related to a prior history of AOP and may be significantly higher than in full-term infants at the postconceptional ages at which hospital discharge now tends to occur.
在87名极低出生体重（VLBW）无症状婴儿出院前进行了呼吸描记图（PG）记录，以确定以下关系：1）早产呼吸暂停（AOP）既往史与心肺模式之间的关系；2）出院时的心肺模式与孕龄之间的关系。有AOP既往史（n = 66）的婴儿与无AOP既往史（n = 21）的婴儿相比，呼吸暂停密度（A6/D%）和最长呼吸暂停时间明显更长（分别为P < 0.05和P < 0.01）。虽然21名无AOP既往史的VLBW婴儿的PG值与足月儿的PG值无显著差异，但66名有AOP既往史的VLBW婴儿的A6/D%（P < 0.01）、周期性呼吸发作次数（P < 0.05）和最长呼吸暂停时间（P < 0.001）与足月儿相比明显更高。与A6/D%值处于正常婴儿第95百分位数范围内的VLBW婴儿相比，A6/D%值较高的VLBW婴儿的孕龄明显更小（中位年龄分别为36周和37.5周；P = 0.01）。因此，准备出院的无症状VLBW婴儿的呼吸模式异常与AOP既往史有关，并且在目前倾向于出院的孕龄时可能明显高于足月儿。
