Pozuelo-Carrascosa Diana P, Cavero-Redondo Iván, Lee I M, Álvarez-Bueno Celia, Reina-Gutierrez Sara, Martínez-Vizcaíno Vicente
Health and Social Care Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain.
Faculty of Physiotherapy and Nursing, Universidad de Castilla-La Mancha, 45004 Toledo, Spain.
J Clin Med. 2021 Mar 25;10(7):1354. doi: 10.3390/jcm10071354.
This work was aimed to synthetize the evidence available about the relationship between resting heart rate (RHR) and the risk of cancer mortality. A computerized search in the Medline, EMBASE, Web of Science, and Cochrane Library databases from their inception to 24 September 2020 was performed. We performed three meta-analyses: (1) cancer mortality comparing the "less than 60 bpm" and "more than 60 bpm" categories; (2) cancer mortality comparing "less than 60 bpm", "60 to 80 bpm", and "more than 80 bpm" categories; and (3) analysis for 10-12 and 20 bpm increase in RHR and risk of cancer mortality. Twenty-two studies were included in the qualitative review, and twelve of them met the inclusion criteria for the meta-analysis. Our results showed a positive association between RHR and the risk of cancer mortality. This association was shown in a meta-analysis comparing studies reporting mean RHR values below and above 60 bpm, when comparing three RHR categories using less than 60 bpm as the reference category and, finally, in dose response analyses estimating the effect of an increase of 10-12 bpm in RHR, both in men and in women. In conclusion, a low RHR is a potential marker of low risk of cancer mortality.
这项研究旨在综合现有的关于静息心率（RHR）与癌症死亡风险之间关系的证据。我们对Medline、EMBASE、科学网和考克兰图书馆数据库进行了计算机检索，检索时间跨度从数据库建立至2020年9月24日。我们进行了三项荟萃分析：（1）比较“低于60次/分钟”和“高于60次/分钟”两组的癌症死亡率；（2）比较“低于60次/分钟”、“60至80次/分钟”和“高于80次/分钟”三组的癌症死亡率；（3）分析静息心率每增加10 - 12次/分钟和20次/分钟与癌症死亡风险的关系。定性综述纳入了22项研究，其中12项符合荟萃分析的纳入标准。我们的结果显示静息心率与癌症死亡风险之间存在正相关。这种相关性在一项荟萃分析中得到体现，该分析比较了静息心率平均值低于和高于60次/分钟的研究报告，在以低于60次/分钟为参照类别比较三个静息心率类别时得到体现，最终在剂量反应分析中也得到体现，该分析估计了静息心率增加10 - 12次/分钟的影响，无论男性还是女性均如此。总之，低静息心率是癌症死亡低风险的一个潜在标志。
