Ho Allen C, Heier Jeffrey S, Holekamp Nancy M, Garfinkel Richard A, Ladd Byron, Awh Carl C, Singh Rishi P, Sanborn George E, Jacobs Jennifer H, Elman Michael J, Loewenstein Anat, Eichenbaum David A
Wills Eye Hospital, 840 Walnut St., Philadelphia, PA 19107, USA.
Ophthalmic Consultants of Boston, 50 Staniford St., Ste. 600, Boston, MA 02114, USA.
J Clin Med. 2021 Mar 25;10(7):1355. doi: 10.3390/jcm10071355.
The real-world performance of a home telemonitoring strategy (ForeseeHome AMD Monitoring System, Notal Vision, Inc.,Manassas VA, USA) was evaluated and compared to the device arm of the AREDS2-HOME study among patients with intermediate AMD (iAMD) who converted to neovascular AMD (nAMD). All patients with confirmed conversion to nAMD who used the home monitoring system from 10/2009 through 9/2018 were identified by Notal Vision Diagnostic Clinic's medical records. Selected outcome variables were evaluated, including visual acuity (VA) at baseline and at conversion, and change in visual acuity (VA) from baseline to time of conversion. In total, 8991 patients performed 3,200,999 tests at a frequency of 5.6 ± 3.2 times/week. The 306 eyes that converted from iAMD to nAMD over the study period (a 2.7% annual rate) were included in the analyses. There was a median (interquartile range) change of -3.0 (0.0-(-10.0)) letters among converted eyes, 81% [95% confidence interval (72-88%)] maintained a VA ≥ 20/40 at the time of conversion, while 69% of the conversion detections were triggered by system alerts. The real-world performance of an at-home testing strategy was similar to that reported for the device arm of the AREDS2-HOME study. The home telemonitoring system can markedly increase early detection of conversion to nAMD.
对一种家庭远程监测策略（ForeseeHome AMD监测系统，Notal Vision公司，美国弗吉尼亚州马纳萨斯）的实际性能进行了评估，并与年龄相关性黄斑变性（AMD）研究2 - 家庭（AREDS2 - HOME）研究中转为新生血管性AMD（nAMD）的中度AMD（iAMD）患者的设备组进行了比较。通过Notal Vision诊断诊所的医疗记录，确定了所有在2009年10月至2018年9月期间使用家庭监测系统且确诊转为nAMD的患者。评估了选定的结果变量，包括基线时和转为nAMD时的视力（VA），以及从基线到转为nAMD时的视力变化。总共8991名患者以每周5.6±3.2次的频率进行了3200999次测试。在研究期间从iAMD转为nAMD的306只眼（年发生率为2.7%）被纳入分析。转为nAMD的眼中，字母数变化的中位数（四分位间距）为 - 3.0（0.0 - (-10.0)），81%[95%置信区间（72 - 88%）]在转为nAMD时保持视力≥20/40，而69%的转为nAMD的检测是由系统警报触发的。家庭检测策略的实际性能与AREDS2 - HOME研究设备组报告的性能相似。家庭远程监测系统可显著提高对转为nAMD的早期检测率。
