Rebelos Eleni, Honka Miikka-Juhani, Ekblad Laura, Bucci Marco, Hannukainen Jarna C, Fernandes Silva Lilian, Virtanen Kirsi A, Nummenmaa Lauri, Nuutila Pirjo
Turku PET Centre, University of Turku, 20520 Turku, Finland.
Turku PET Centre, Turku University Hospital, 20521 Turku, Finland.
J Clin Med. 2021 Mar 23;10(6):1312. doi: 10.3390/jcm10061312.
The melanocortin system is involved in the control of adiposity through modulation of food intake and energy expenditure. The single nucleotide polymorphism (SNP) rs17782313 near the gene has been linked to obesity, and a previous study using magnetoencephalography has shown that carriers of the mutant allele have decreased cerebrocortical response to insulin. Thus, in this study, we addressed whether rs17782313 associates with brain glucose uptake (BGU). Here, [F]-fluorodeoxyglucose positron emission tomography (PET) data from 113 Finnish subjects scanned under insulin clamp conditions who also had the rs17782313 determined were compiled from a single-center cohort. BGU was quantified by the fractional uptake rate. Statistical analysis was performed with statistical parametric mapping. There was no difference in age, BMI, and insulin sensitivity as indexed by the M value between the rs17782313-C allele carriers and non-carriers. Brain glucose uptake during insulin clamp was not different by gene allele, and it correlated with the M value, in both the rs17782313-C allele carriers and non-carriers. The obesity risk SNP rs17782313 near the gene is not associated with brain glucose uptake during insulin clamp in humans, and this frequent mutation cannot explain the enhanced brain glucose metabolic rates in insulin resistance.
黑皮质素系统通过调节食物摄入和能量消耗参与肥胖的控制。该基因附近的单核苷酸多态性（SNP）rs17782313与肥胖有关，先前一项使用脑磁图的研究表明，突变等位基因携带者对胰岛素的脑皮质反应降低。因此，在本研究中，我们探讨了rs17782313是否与脑葡萄糖摄取（BGU）相关。在这里，我们从一个单中心队列中收集了113名芬兰受试者在胰岛素钳夹条件下扫描的[F] - 氟脱氧葡萄糖正电子发射断层扫描（PET）数据，这些受试者的rs17782313也已确定。通过分数摄取率对BGU进行量化。使用统计参数映射进行统计分析。rs17782313 - C等位基因携带者和非携带者之间在年龄、体重指数和以M值为指标的胰岛素敏感性方面没有差异。胰岛素钳夹期间的脑葡萄糖摄取在基因等位基因之间没有差异，并且在rs17782313 - C等位基因携带者和非携带者中均与M值相关。该基因附近的肥胖风险SNP rs17782313与人类胰岛素钳夹期间的脑葡萄糖摄取无关，这种常见突变无法解释胰岛素抵抗中脑葡萄糖代谢率的升高。
