Padula Stephanie L, Velayutham Nivedhitha, Yutzey Katherine E
The Heart Institute, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Molecular and Developmental Biology Graduate Program, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Int J Mol Sci. 2021 Mar 23;22(6):3288. doi: 10.3390/ijms22063288.
During the postnatal period, mammalian cardiomyocytes undergo numerous maturational changes associated with increased cardiac function and output, including hypertrophic growth, cell cycle exit, sarcomeric protein isoform switching, and mitochondrial maturation. These changes come at the expense of loss of regenerative capacity of the heart, contributing to heart failure after cardiac injury in adults. While most studies focus on the transcriptional regulation of embryonic or adult cardiomyocytes, the transcriptional changes that occur during the postnatal period are relatively unknown. In this review, we focus on the transcriptional regulators responsible for these aspects of cardiomyocyte maturation during the postnatal period in mammals. By specifically highlighting this transitional period, we draw attention to critical processes in cardiomyocyte maturation with potential therapeutic implications in cardiovascular disease.
在出生后的时期，哺乳动物的心肌细胞经历了许多与心脏功能和输出增加相关的成熟变化，包括肥大性生长、细胞周期退出、肌节蛋白异构体转换和线粒体成熟。这些变化是以心脏再生能力丧失为代价的，这导致成年后心脏损伤后发生心力衰竭。虽然大多数研究集中在胚胎或成年心肌细胞的转录调控上，但出生后时期发生的转录变化相对未知。在这篇综述中，我们关注负责哺乳动物出生后时期心肌细胞成熟这些方面的转录调节因子。通过特别强调这个过渡时期，我们提请注意心肌细胞成熟中的关键过程，这些过程在心血管疾病中具有潜在的治疗意义。
