Institute of Developmental Psychology, Beijing Normal University, Beijing 100875, China.
Int J Environ Res Public Health. 2021 Mar 5;18(5):2598. doi: 10.3390/ijerph18052598.
(1) Background: Numerous studies suggest strong associations between childhood maltreatment and nonsuicidal self-injury (NSSI); this is also true for the roles of dopaminergic genes in the etiology of some psychopathologies related to NSSI. Investigating the interactions of environments and genes is important in order to better understand the etiology of NSSI. (2) Methods: Within a sample of 269 Chinese male adolescents (age = 14.72, = 0.92), childhood maltreatment and NSSI were evaluated, and saliva samples were collected for MAOA T941G and COMT Val158Met polymorphism analyses. (3) Results: The results revealed no primary effects attributable to MAOA T941G and COMT Val158Met polymorphism on NSSI. However, there was a significant three-way interaction between MAOA, COMT, and child abuse (β = -0.34, < 0.01) in adolescent NSSI. Except for carriers of the T allele of MAOA and the Met allele of COMT, all studied male adolescents displayed higher NSSI scores when exposed to a higher level of child abuse. A similar three-way interaction was not observed in the case of child neglect. (4) Conclusions: The results indicate that the MAOA gene and COMT gene play moderating roles in the association between child abuse and NSSI of male adolescents and suggest the polygenic underpinnings of NSSI.
(1) 背景：大量研究表明，儿童期虐待与非自杀性自伤（NSSI）之间存在强烈关联；多巴胺能基因在某些与 NSSI 相关的精神病理学的发病机制中也有同样的作用。研究环境和基因的相互作用对于更好地理解 NSSI 的发病机制非常重要。(2) 方法：在 269 名中国男性青少年样本中（年龄=14.72，=0.92），评估了儿童期虐待和 NSSI 情况，并采集了唾液样本进行 MAOA T941G 和 COMT Val158Met 多态性分析。(3) 结果：结果显示，MAOA T941G 和 COMT Val158Met 多态性对 NSSI 没有直接影响。然而，在青少年 NSSI 中，MAOA、COMT 和儿童虐待之间存在显著的三向交互作用（β=-0.34，<0.01）。除了 MAOA 的 T 等位基因和 COMT 的 Met 等位基因的携带者外，所有研究的男性青少年在暴露于更高水平的儿童虐待时，NSSI 评分更高。在儿童忽视的情况下，没有观察到类似的三向相互作用。(4) 结论：结果表明，MAOA 基因和 COMT 基因在儿童虐待与男性青少年 NSSI 之间的关联中起调节作用，并提示 NSSI 的多基因基础。
