Zhao Meng, Feng Jie, Wang Lu-Yao, Zhou Bo
Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 611135, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2024 Dec 15;26(12):1322-1328. doi: 10.7499/j.issn.1008-8830.2407115.
To investigate the interaction between catechol-O-methyltransferase () gene polymorphisms and childhood trauma in adolescents with non-suicidal self-injury (NSSI), and to provide a basis for the prevention and intervention of NSSI among adolescents.
A total of 84 adolescents with NSSI and 87 healthy controls were enrolled in this study. Oral saliva samples were collected for genotyping of the gene at rs4680 and rs165599. Childhood Trauma Questionnaire, Behavioral Function Assessment Scale of Non-suicidal Self-injury in Adolescents, and Patient Health Questionnaire-9 Items were used for mental health assessment. A hierarchical linear regression analysis was used to examine the main effect and interactive effect of gene polymorphisms at rs4680 and rs165599 and childhood trauma on NSSI. The Johnson-Neyman technique was used to identify the regions where the moderating variables had a significant impact.
The interaction between gene polymorphisms at rs165599 and the subtype of emotional neglect in childhood trauma could predict NSSI in adolescents (=0.251, =2.329, =0.022). As for the adolescents carrying the G/G genotype at rs165599, the high emotional neglect group had a significantly higher NSSI score than the low emotional neglect group (=4.579, =0.049).
Adolescents carrying the G/G genotype at rs165599 of the gene may have an increase in susceptibility to NSSI in case of high emotional neglect in childhood.
探讨儿茶酚-O-甲基转移酶（COMT）基因多态性与非自杀性自伤（NSSI）青少年童年创伤之间的相互作用，为青少年NSSI的预防和干预提供依据。
本研究共纳入84例NSSI青少年和87例健康对照。采集口腔唾液样本，对COMT基因rs4680和rs165599位点进行基因分型。采用儿童创伤问卷、青少年非自杀性自伤行为功能评估量表和患者健康问卷9条目进行心理健康评估。采用分层线性回归分析检验rs4680和rs165599位点COMT基因多态性及童年创伤对NSSI的主效应和交互效应。采用约翰逊-奈曼技术确定调节变量具有显著影响的区域。
rs165599位点COMT基因多态性与童年创伤中情感忽视亚型之间的相互作用可预测青少年的NSSI（β=0.251，t=2.329，P=0.022）。对于rs165599位点携带G/G基因型的青少年，高情感忽视组的NSSI得分显著高于低情感忽视组（t=4.579，P=0.049）。
COMT基因rs165599位点携带G/G基因型的青少年在童年时期遭受高情感忽视时，发生NSSI的易感性可能增加。
