Aly S A, Udeala O K
Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka.
Pharmazie. 1988 Mar;43(3):188-90.
Fast flow lactose (FFL) and anhydrous lactose (AHL) were comparatively investigated for the manufacture of pyridoxine hydrochloride tablets. The results showed that drug/FFL formulations possessed better performance. Harder tablets were, however, compressed from AHL blends. Linear relationships which correlate tablet physical properties to excipient concentration in a given formulation were established. Tablet batches formulated with FFL dissolved in shorter times und showed better stability characteristics on aging.
对速流乳糖（FFL）和无水乳糖（AHL）在盐酸吡哆辛片生产中的应用进行了对比研究。结果表明，药物/FFL制剂具有更好的性能。然而，由AHL混合物压制出的片剂硬度更高。建立了在给定制剂中，将片剂物理性质与辅料浓度相关联的线性关系。用FFL配制的片剂批次溶解时间更短，并且在老化时表现出更好的稳定性特征。
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