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首例耐碳青霉烯类菌血症病例

First Case of Bacteraemia Due to Carbapenem-Resistant .

作者信息

Kaeuffer Charlotte, Ruge Tiffany, Diancourt Laure, Romain Benoît, Ruch Yvon, Jaulhac Benoît, Boyer Pierre H

机构信息

Department of Infectious Disease, Strasbourg University Hospital, 67000 Strasbourg, France.

Laboratory of Bacteriology, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.

出版信息

Antibiotics (Basel). 2021 Mar 19;10(3):319. doi: 10.3390/antibiotics10030319.

DOI:10.3390/antibiotics10030319
PMID:33808699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8003481/
Abstract

Multidrug resistant (MDR) bacteria are increasingly observed in nosocomial and community-acquired settings. Anaerobes are no exception to this rule, but there are fewer reports of MDR in the scientific literature on anaerobes than there are for other bacteria. In this short case report, we describe the first case of bacteraemia caused by a multidrug-resistant , which produces a carbapenemase encoded by the gene. This bacteraemia followed a digestive surgery operation. Surprisingly, these findings did not lead to a change in antibiotic therapy, probably because the patient's clinical state had improved. Nevertheless this report calls for better knowledge of anaerobic bacteria and for a systematic antimicrobial stewardship procedure following bacteraemia.

摘要

在医院和社区获得性感染环境中,多重耐药(MDR)细菌越来越常见。厌氧菌也不例外,但与其他细菌相比,科学文献中关于厌氧菌多重耐药的报道较少。在本简短病例报告中,我们描述了首例由一株产生由 基因编码的碳青霉烯酶的多重耐药菌引起的菌血症病例。该菌血症发生在一次消化外科手术后。令人惊讶的是,这些发现并未导致抗生素治疗方案的改变,可能是因为患者的临床状况已有所改善。尽管如此,本报告呼吁提高对厌氧菌的认识,并在菌血症发生后实施系统的抗菌药物管理程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910a/8003481/90bf56c1e784/antibiotics-10-00319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910a/8003481/90bf56c1e784/antibiotics-10-00319-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/910a/8003481/90bf56c1e784/antibiotics-10-00319-g001.jpg

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本文引用的文献

1
Antimicrobial susceptibility and prevalence of resistance genes in Bacteroides fragilis isolated from blood culture bottles in two tertiary care hospitals in Japan.从日本两家三级护理医院的血培养瓶中分离出脆弱拟杆菌的抗菌药敏性和耐药基因流行情况。
Anaerobe. 2020 Aug;64:102215. doi: 10.1016/j.anaerobe.2020.102215. Epub 2020 Jun 20.
2
First case report of a human sepsis involving a recently identified anaerobic agent: Bacteroides faecis.首例涉及最近鉴定出的厌氧病原体——粪拟杆菌的人类败血症病例报告。
Anaerobe. 2016 Dec;42:74-77. doi: 10.1016/j.anaerobe.2016.08.004. Epub 2016 Aug 18.
3
Infectious disease consultation for Staphylococcus aureus bacteremia - A systematic review and meta-analysis.
通过基因组测序和功能分析发现木聚糖拟杆菌中的一种新型金属β-内酰胺酶(MBL)及其基因(crxA)。
J Antimicrob Chemother. 2022 May 29;77(6):1553-1556. doi: 10.1093/jac/dkac088.
4
Broth Microdilution and Gradient Diffusion Strips vs. Reference Agar Dilution Method: First Evaluation for Species Antimicrobial Susceptibility Testing.肉汤微量稀释法和梯度扩散条带法与参考琼脂稀释法的比较:首次用于菌种抗菌药敏试验的评估
Antibiotics (Basel). 2021 Aug 12;10(8):975. doi: 10.3390/antibiotics10080975.
金黄色葡萄球菌菌血症的感染病会诊:系统评价和荟萃分析。
J Infect. 2016 Jan;72(1):19-28. doi: 10.1016/j.jinf.2015.09.037. Epub 2015 Oct 9.
4
Bacteroides faecis and Bacteroides intestinalis recovered from clinical specimens of human intestinal origin.从人类肠道来源的临床标本中分离出的粪拟杆菌和肠道拟杆菌。
Yonsei Med J. 2015 Jan;56(1):292-4. doi: 10.3349/ymj.2015.56.1.292.
5
High rates of reduced susceptibility in the Bacteroides fragilis group isolated from blood cultures--the first national survey in Denmark.从血培养中分离出的脆弱拟杆菌群药敏降低率较高——丹麦首次全国性调查
Int J Antimicrob Agents. 2013 Aug;42(2):188-90. doi: 10.1016/j.ijantimicag.2013.04.025. Epub 2013 Jun 15.
6
Antimicrobial susceptibility of Bacteroides fragilis group isolates in Europe: 20 years of experience.欧洲脆弱拟杆菌群分离株的抗菌药敏性:20 年的经验。
Clin Microbiol Infect. 2011 Mar;17(3):371-9. doi: 10.1111/j.1469-0691.2010.03256.x.
7
The role of anaerobic bacteria in bacteremia.厌氧菌在菌血症中的作用。
Anaerobe. 2010 Jun;16(3):183-9. doi: 10.1016/j.anaerobe.2009.12.001. Epub 2009 Dec 16.
8
Bacteroides faecis sp. nov., isolated from human faeces.粪拟杆菌新种,从人粪便中分离得到。
Int J Syst Evol Microbiol. 2010 Nov;60(Pt 11):2572-2576. doi: 10.1099/ijs.0.020024-0. Epub 2009 Dec 11.
9
Bacteroides fragilis BmeABC efflux systems additively confer intrinsic antimicrobial resistance.脆弱拟杆菌BmeABC外排系统可累加赋予内在抗微生物耐药性。
J Antimicrob Chemother. 2006 Jul;58(1):37-46. doi: 10.1093/jac/dkl202. Epub 2006 Jun 6.
10
Penicillin-binding proteins of Bacteroides fragilis and their role in the resistance to imipenem of clinical isolates.脆弱拟杆菌的青霉素结合蛋白及其在临床分离株对亚胺培南耐药性中的作用。
J Med Microbiol. 2005 Nov;54(Pt 11):1055-1064. doi: 10.1099/jmm.0.45930-0.