The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer.

N6-methyladenosine (mA) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The mA modification is a dynamic and reversible process, regulated by three kinds of regulator, including mA methyltransferases, demethylases and mA-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the mA modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various mA regulators modulate mA RNA metabolism and demonstrated the effect of mA modification on the progression and cellular biological functions of NSCLC. We also discussed how mA modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients.