Bardach J, Kelly K M, Jakobsen J R
Cleft Palate Center, University of Iowa Hospitals and Clinics, Iowa City.
Plast Reconstr Surg. 1988 Jul;82(1):31-41.
This study was designed to test the hypothesis that simultaneous lip and palate repair results in more severe craniofacial growth aberrations than lip repair or palate repair performed separately. Seventy-six purebred beagles were divided into five groups. Two of these groups were controls (unoperated and unrepaired animals); the three remaining groups were experimental (in one group only the lip was repaired, in another only the palate was repaired, and in the last the lip and palate were repaired simultaneously). Cephalometric measurements were analyzed using univariate and multivariate statistical techniques. In multivariate analysis, stepwise multiple regression and discrimination were applied to precisely assess the effects of the various surgical procedures. The results of this study indicate that simultaneous lip and palate repair results in more severe craniofacial growth aberrations than lip repair or palate repair performed separately.
与单独进行唇修复或腭裂修复相比，同期唇腭裂修复会导致更严重的颅面生长畸形。76只纯种比格犬被分为五组。其中两组为对照组（未手术和未修复的动物）；其余三组为实验组（一组仅修复唇，另一组仅修复腭裂，最后一组同期修复唇和腭裂）。使用单变量和多变量统计技术分析头影测量数据。在多变量分析中，应用逐步多元回归和判别分析来精确评估各种手术方法的效果。本研究结果表明，与单独进行唇修复或腭裂修复相比，同期唇腭裂修复会导致更严重的颅面生长畸形。
