Bardach J, Roberts D M, Yale R, Rosewall D, Mooney M
Cleft Palate J. 1980 Oct;17(4):309-18.
This study was designed to test the influence of simultaneous cleft lip and palate repair on facial growth in rabbits. Three groups of rabbits were used. Group I consisted of control rabbits who had no surgery; Group II had surgically created, but unrepaired, clefts of the lip, alveolus, and palate; and Group III had surgically created clefts of the lip, alveolus, and palate followed by immediate simultaneous lip and palate repair. In Group III, the lip was repaired using the Millare technique and the palate using two-flap palatoplasty, leaving no bare bone exposed. All animals were sacrificed after twenty weeks. Results of the direct cephalometry of the skulls confirmed that simultaneous lip and palate repair results in inhibition of anterior-posterior and transverse maxillary growth. Some significant changes were also found in mandibular length and nasal deflection. All 15 rabbits with simultaneous cleft lip and palate repair developed anterior crossbites and functional shifts to the left or cleft side. Further analysis comparing the results of facial growth inhibition in this study with inhibition following lip repair only or palate repair only will be necessary to assess the severity of secondary maxillo-facial deformities resulting from lip and palate repair.
本研究旨在测试同期唇腭裂修复对兔面部生长的影响。使用了三组兔子。第一组为未接受手术的对照兔；第二组通过手术制造唇、牙槽突和腭裂，但未进行修复；第三组通过手术制造唇、牙槽突和腭裂，随后立即进行同期唇腭裂修复。在第三组中，唇采用Millare技术修复，腭裂采用双瓣腭成形术修复，无裸露骨面。所有动物在20周后处死。对头骨进行直接头影测量的结果证实，同期唇腭裂修复会抑制上颌前后向和横向生长。在下颌长度和鼻偏斜方面也发现了一些显著变化。所有15只接受同期唇腭裂修复的兔子均出现前牙反合，并向左侧或腭裂侧发生功能性移位。为了评估唇腭裂修复导致的继发颌面畸形的严重程度，有必要进一步分析本研究中面部生长抑制的结果与仅唇修复或仅腭裂修复后的抑制结果进行比较。
