Grigore Raluca, Popescu Bogdan, Berteşteanu Şerban Vifor Gabriel, Nichita Cornelia, Oașă Irina Doinita, Munteanu Gloria Simona, Nicolaescu Alexandru, Bejenaru Paula Luiza, Simion-Antonie Catrinel Beatrice, Ene Dragoș, Ene Răzvan
Otorhynolaryngology Department, Colțea Clinical Hospital, 917151 Bucharest, Romania.
Department 12-Otorhynolaryngology, Ophtalmology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Materials (Basel). 2021 Mar 16;14(6):1436. doi: 10.3390/ma14061436.
This study aims to establish whether the use of biomaterials, particularly polydimethylsiloxane (PDMS), for surgical reconstruction of the esophagus with templates, Montgomery salivary tube, after radical oncology surgery for malignant neoplasia is an optimal choice for patients' safety and for optimal function preservation and organ rehabilitation. Structural analysis by Raman spectrometry and biomechanical properties with dynamic mechanical analysis are performed for fatigue strength and toughness, essential factors in durability of a prosthesis in the reconstruction practice of the esophagus. Nanocomposites with silicone elastomers and nanoparticles used in implantable devices and in reconstruction surgery present risks of infection and fatigue strength when required to perform a mechanical effort for long periods of time. This report takes into account the effect of silver (Ag) nanoparticles on the fatigue strength using polydimethylsiloxane (PDMS) matrix, representative for silicon elastomers used in implantable devices. PDMS with 5% (wt) Ag nanoparticles of 100-150 nm during mechanical fatigue testing at shear strength loses elasticity properties after 400 loading-unloading cycles and up to 15% shear strain. The fatigue strength, toughness, maximum shear strength, as well as clinical properties are key issues in designing Montgomery salivary tube and derivates with appropriate biomechanical behavior for each patient. Prosthesis design needs to indulge both clinical outcomes as well as design methods and research in the field of biomaterials.
本研究旨在确定在恶性肿瘤根治性肿瘤手术后，使用生物材料，特别是聚二甲基硅氧烷（PDMS），通过模板（蒙哥马利唾液管）进行食管手术重建，对于患者安全以及最佳功能保留和器官康复而言是否是最佳选择。通过拉曼光谱进行结构分析，并采用动态力学分析研究生物力学性能，以考察疲劳强度和韧性，这是食管重建实践中假体耐久性的关键因素。用于植入式设备和重建手术的含硅弹性体和纳米颗粒的纳米复合材料，在需要长时间进行机械作用时存在感染风险和疲劳强度问题。本报告考虑了银（Ag）纳米颗粒对使用聚二甲基硅氧烷（PDMS）基质的疲劳强度的影响，该基质代表了用于植入式设备的硅弹性体。在剪切强度下进行机械疲劳测试时，含有5%（重量）100 - 150 nm银纳米颗粒的PDMS，在400次加载 - 卸载循环和高达15%的剪切应变后失去弹性性能。疲劳强度、韧性、最大剪切强度以及临床特性是设计蒙哥马利唾液管及其衍生物的关键问题，这些衍生物要为每个患者具备适当的生物力学行为。假体设计需要兼顾临床结果以及生物材料领域的设计方法和研究。
