Grao-Cruces Elena, Varela Lourdes M, Martin Maria E, Bermudez Beatriz, Montserrat-de la Paz Sergio
Department of Medical Biochemistry, Molecular Biology and Immunology, School of Medicine, University of Seville, 41009 Seville, Spain.
Institute of Biomedicine of Seville, IBiS, Universitary Hospital Virgen del Rocio/CSIC/University of Seville, 41013 Seville, Spain.
Nutrients. 2021 Mar 16;13(3):955. doi: 10.3390/nu13030955.
Cardiovascular disease (CVD) is the leading cause of global mortality and the study of high-density lipoproteins (HDL) particle composition and functionality has become a matter of high interest, particularly in light to the disappointing clinical data for HDL-cholesterol (HDL-C) raising therapies in CVD secondary prevention and the lack of association between HDL-C and the risk of CVD. Recent evidences suggest that HDL composition and functionality could be modulated by diet. The purpose of this systematic review was to investigate the effect of Mediterranean diet (MD) on changes in HDL structure and functionality in humans. A comprehensive search was conducted in four databases (PubMed, Scopus, Cochrane library and Web of Science) and 13 records were chosen. MD showed favorable effects on HDL functionality, particularly by improving HDL cholesterol efflux capacity and decreasing HDL oxidation. In addition, HDL composition and size were influenced by MD. Thus, MD is a protective factor against CVD associated with the improvement of HDL quality and the prevention of HDL dysfunctionality.
心血管疾病（CVD）是全球死亡的主要原因，对高密度脂蛋白（HDL）颗粒组成和功能的研究已成为备受关注的问题，特别是鉴于HDL胆固醇（HDL-C）升高疗法在CVD二级预防中的临床数据令人失望，以及HDL-C与CVD风险之间缺乏关联。最近的证据表明，HDL的组成和功能可通过饮食调节。本系统评价的目的是研究地中海饮食（MD）对人体HDL结构和功能变化的影响。在四个数据库（PubMed、Scopus、Cochrane图书馆和Web of Science）中进行了全面检索，共筛选出13篇记录。MD对HDL功能有积极影响，特别是通过提高HDL胆固醇流出能力和减少HDL氧化。此外，MD还会影响HDL的组成和大小。因此，MD是预防CVD的保护因素，与HDL质量改善和HDL功能障碍预防相关。
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