Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, Av. Sanchez Pizjuan s/n, 41009 Seville, Spain.
Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío, CSIC, University of Seville, 41013 Seville, Spain.
Nutrients. 2024 May 23;16(11):1594. doi: 10.3390/nu16111594.
Plant protein is considered a sustainable health-promoting strategy to prevent metabolic syndrome. Lifestyle changes (including dietary patterns and exercise) have been demonstrated to exert an effect on human health by modulating the biochemical status in humans. The objective of this study was to assess whether supplementation with hemp protein within a Mediterranean diet context together with exercise could help to ameliorate the metabolic statuses of patients prone to developing metabolic syndrome. For this study, 23 patients followed with Mediterranean diet and engaged in aerobic exercise according to the WHO's recommendations, while also being supplemented with hemp protein, for 12 weeks. A comparison of anthropometric, biochemical, and mineral data as well as amino acid values was made between the start and the end of the study, with the subjects acting as their own control group. Statistical analyses included a paired -test, Wilcoxon paired test, Pearson correlation coefficient, and Sparse Partial Least Squares Discriminant Analysis to evaluate significant differences and correlations among parameters. There were statistically significant changes in total cholesterol, HDL-C (+52.3%), LDL-C (-54.0%), and TAG levels (-49.8%), but not in glucose plasma levels. Following the intervention, plasma concentrations of some amino acids, including α-aminoadipic acid, phosphoethanolamine, and 1-metylhistidine, increased, whereas those of asparagine and alanine declined. Different correlations between amino acids and the other parameters evaluated were reported and discussed. A Mediterranean diet combined with regular aerobic exercise, together with protein supplementation, can highly improve the metabolic parameters and anthropometric parameters of subjects with obesity and impaired glucose levels, ameliorating their health status and likely delaying the development of metabolic syndrome.
植物蛋白被认为是一种促进健康的可持续策略，可预防代谢综合征。生活方式的改变（包括饮食模式和运动）已被证明可以通过调节人类的生化状态对人类健康产生影响。本研究的目的是评估在富含地中海饮食的环境中补充大麻蛋白并结合运动是否有助于改善易患代谢综合征的患者的代谢状态。在这项研究中，23 名患者遵循地中海饮食，并根据世界卫生组织的建议进行有氧运动，同时补充大麻蛋白，为期 12 周。在研究开始和结束时，对人体测量学、生化和矿物质数据以及氨基酸值进行了比较，患者自身作为对照组。统计分析包括配对检验、Wilcoxon 配对检验、皮尔逊相关系数和稀疏偏最小二乘判别分析，以评估参数之间的显著差异和相关性。总胆固醇、HDL-C（+52.3%）、LDL-C（-54.0%）和 TAG 水平（-49.8%）有统计学显著变化，但血糖水平没有变化。干预后，一些氨基酸的血浆浓度增加，包括α-氨基己二酸、磷酸乙醇胺和 1-甲基组氨酸，而天冬酰胺和丙氨酸的浓度下降。报告并讨论了氨基酸与其他评估参数之间的不同相关性。地中海饮食结合规律的有氧运动，再加上蛋白质补充，可以显著改善肥胖和血糖水平受损患者的代谢和人体测量参数，改善他们的健康状况，并可能延缓代谢综合征的发展。
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