目前针对与心血管疾病相关的高密度脂蛋白的治疗方法。
Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease.
机构信息
Instituto Nacional de Cardiología "Ignacio Chávez" Juan Badiano No. 1, Belisario Domínguez Sección 16, 14080 Tlalpan, Mexico City, Mexico.
Facultad de Nutrición, Universidad Autónoma del Estado de Morelos, UAEM, Calle Río Iztaccihuatl S/N, Vista Hermosa, 62350 Cuernavaca, Morelos, Mexico.
出版信息
Molecules. 2018 Oct 23;23(11):2730. doi: 10.3390/molecules23112730.
High-density lipoproteins (HDL) comprise a heterogeneous family of lipoprotein particles divided into subclasses that are determined by density, size and surface charge as well as protein composition. Epidemiological studies have suggested an inverse correlation between High-density lipoprotein-cholesterol (HDL-C) levels and the risk of cardiovascular diseases and atherosclerosis. HDLs promote reverse cholesterol transport (RCT) and have several atheroprotective functions such as anti-inflammation, anti-thrombosis, and anti-oxidation. HDLs are considered to be atheroprotective because they are associated in serum with paraoxonases (PONs) which protect HDL from oxidation. Polyphenol consumption reduces the risk of chronic diseases in humans. Polyphenols increase the binding of HDL to PON1, increasing the catalytic activity of PON1. This review summarizes the evidence currently available regarding pharmacological and alternative treatments aimed at improving the functionality of HDL-C. Information on the effectiveness of the treatments has contributed to the understanding of the molecular mechanisms that regulate plasma levels of HDL-C, thereby promoting the development of more effective treatment of cardiovascular diseases. For that purpose, Scopus and Medline databases were searched to identify the publications investigating the impact of current therapies focused on high-density lipoproteins.
高密度脂蛋白（HDL）由一组具有异质性的脂蛋白颗粒组成，这些颗粒根据密度、大小和表面电荷以及蛋白质组成进行分类。流行病学研究表明，高密度脂蛋白胆固醇（HDL-C）水平与心血管疾病和动脉粥样硬化的风险呈负相关。HDL 促进胆固醇的逆向转运（RCT），并具有多种抗动脉粥样硬化功能，如抗炎、抗血栓形成和抗氧化。HDL 被认为具有抗动脉粥样硬化作用，因为它们在血清中与对氧磷酶（PONs）相关，PONs 可以保护 HDL 免受氧化。多酚的摄入可降低人类患慢性病的风险。多酚增加了 HDL 与 PON1 的结合，从而提高了 PON1 的催化活性。本综述总结了目前关于旨在改善 HDL-C 功能的药理学和替代治疗的证据。关于这些治疗方法有效性的信息有助于理解调节血浆 HDL-C 水平的分子机制，从而促进开发更有效的心血管疾病治疗方法。为此，检索了 Scopus 和 Medline 数据库，以确定调查当前针对高密度脂蛋白的治疗方法的影响的出版物。
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