Rehr R B, Tatum J L, Hirsch J I, Wetstein L, Clarke G
Department of Radiology, Virginia Commonwealth University Health Sciences Division, Medical College of Virginia, Richmond 23298-0001.
Radiology. 1988 Jul;168(1):81-9. doi: 10.1148/radiology.168.1.3380986.
The ability of phosphorus-31 magnetic resonance (MR) spectroscopy to accurately characterize myocardium as normal, ischemic, or reperfused but viable was examined in the canine model of acute coronary artery occlusion. P-31 MR measurements of in vivo myocardial pH, phosphocreatine, adenosine triphosphate, and inorganic phosphate levels were made at baseline and for 6 hours after sustained coronary occlusion (ten animals) or coronary occlusion reperfused after 60 minutes (12 animals). Ten control animals were studied in parallel fashion, without coronary occlusion. Myocardial tissue characterization derived from the P-31 MR spectroscopy data by logistic regression analysis had an overall accuracy of 89%. Overall accuracy was unaffected by duration between coronary occlusion and P-31 MR study. Thus, metabolic data obtained with P-31 MR spectroscopy effectively separate normal, acutely ischemic, and reperfused but viable myocardium.
在急性冠状动脉闭塞犬模型中，研究了磷-31磁共振（MR）波谱准确鉴别心肌为正常、缺血或再灌注但存活的能力。在基线时以及持续冠状动脉闭塞6小时后（10只动物）或60分钟后冠状动脉闭塞再灌注（12只动物），对体内心肌pH、磷酸肌酸、三磷酸腺苷和无机磷水平进行了磷-31 MR测量。以平行方式研究了10只对照动物，未进行冠状动脉闭塞。通过逻辑回归分析从磷-31 MR波谱数据得出的心肌组织特征总体准确率为89%。总体准确率不受冠状动脉闭塞与磷-31 MR研究之间持续时间的影响。因此，用磷-31 MR波谱获得的代谢数据可有效区分正常、急性缺血和再灌注但存活的心肌。
