1,3-环己二烯-1-醛：合成、反应活性与生物活性。

1,3-Cyclohexadien-1-Als: Synthesis, Reactivity and Bioactivities.

机构信息

Departamento de Química Orgánica, Facultad de Ciencias Químicas, University of Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.

Departamento de Ciencias Farmacéuticas, Facultad de Farmacia, CIETUS, IBSAL, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.

出版信息

Molecules. 2021 Mar 22;26(6):1772. doi: 10.3390/molecules26061772.

DOI:10.3390/molecules26061772

PMID:33809941

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8004145/

Abstract

In synthetic organic chemistry, there are very useful basic compounds known as building blocks. One of the main reactions wherein they are applied for the synthesis of complex molecules is the Diels-Alder cycloaddition. This reaction is between a diene and a dienophile. Among the most important dienes are the cyclic dienes, as they facilitate the reaction. This review considers the synthesis and reactivity of one of these dienes with special characteristics-it is cyclic and has an electron withdrawing group. This building block has been used for the synthesis of biologically active compounds and is present in natural compounds with interesting properties.

摘要

在合成有机化学中，有非常有用的基本化合物，称为构建块。其中一种主要的反应是 Diels-Alder 环加成反应，用于合成复杂分子。该反应发生在二烯和双烯之间。最重要的二烯之一是环状二烯，因为它们促进了反应的进行。这篇综述考虑了具有特殊性质的环状二烯之一的合成和反应性-它是环状的并且具有吸电子基团。该构建块已用于合成具有生物活性的化合物，并且存在于具有有趣性质的天然化合物中。