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过氧化物酶体增殖性降血脂药物对大鼠和小鼠血清芳基酯酶及胆碱酯酶活性水平的影响。

Effect of peroxisome proliferating hypolipidemic agents on serum activity levels of arylesterase and cholinesterase in rats and mice.

作者信息

Butler E G, England P J, Williams G M

机构信息

American Health Foundation, Valhalla, New York 10595.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):125-8.

PMID:3381006
Abstract

The effect of dietary exposures to peroxisome-proliferating, hypolipidemic agents on serum esterases was determined in rats and mice. Four genotypes of mice were fed nafenopin (1000 ppm) for six weeks and clofibrate (5000 ppm) was fed to young and aged rats for three weeks. The exposures significantly increased serum cholinesterase activity levels and decreased serum arylesterase activity levels in all groups of both species.

摘要

在大鼠和小鼠中测定了饮食接触过氧化物酶体增殖性降血脂剂对血清酯酶的影响。给四种基因型的小鼠喂食萘酚平(1000 ppm)六周,给年轻和老年大鼠喂食氯贝丁酯(5000 ppm)三周。在这两个物种的所有组中,这些接触显著提高了血清胆碱酯酶活性水平,并降低了血清芳基酯酶活性水平。

相似文献

1
Effect of peroxisome proliferating hypolipidemic agents on serum activity levels of arylesterase and cholinesterase in rats and mice.过氧化物酶体增殖性降血脂药物对大鼠和小鼠血清芳基酯酶及胆碱酯酶活性水平的影响。
Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):125-8.
2
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Cancer Res. 1980 Jan;40(1):36-41.
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Increase in hepatic carnitine acetyltransferase activity associated with peroxisomal (microbody) proliferation induced by the hypolipidemic drugs clofibrate, nafenopin, and methyl clofenapate.降血脂药物氯贝丁酯、萘酚平及氯苯酯诱导的过氧化物酶体(微体)增殖与肝脏肉碱乙酰转移酶活性增加有关。
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NTP Toxicology and Carcinogenesis Studies of Ethylene Thiourea (CAS: 96-45-7) in F344 Rats and B6C3F1 Mice (Feed Studies).NTP对F344大鼠和B6C3F1小鼠进行的乙硫脲(CAS:96-45-7)毒理学和致癌性研究(饲料喂养研究)
Natl Toxicol Program Tech Rep Ser. 1992 Mar;388:1-256.
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Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.降血脂药物氯贝丁酯对低铁饮食喂养大鼠铁调节蛋白IRP1和IRP2活性及肝脏铁代谢的影响
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An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.在转基因小鼠中,烯酰辅酶A水合酶/3-羟酰基辅酶A脱氢酶基因的上游区域可指导荧光素酶在肝脏中表达,以响应过氧化物酶体增殖剂。
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Two hypolipidemic peroxisome proliferators increase the number of lamellar bodies in alveolar cells type II of the rat lung.
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引用本文的文献

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Arylesterase phenotype-specific positive association between arylesterase activity and cholinesterase specific activity in human serum.人血清中芳基酯酶活性与胆碱酯酶比活性之间的芳基酯酶表型特异性正相关。
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