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Increase in hepatic carnitine acetyltransferase activity associated with peroxisomal (microbody) proliferation induced by the hypolipidemic drugs clofibrate, nafenopin, and methyl clofenapate.

作者信息

Moody D E, Reddy J K

出版信息

Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):501-10.

PMID:4445568
Abstract
摘要

相似文献

1
Increase in hepatic carnitine acetyltransferase activity associated with peroxisomal (microbody) proliferation induced by the hypolipidemic drugs clofibrate, nafenopin, and methyl clofenapate.降血脂药物氯贝丁酯、萘酚平及氯苯酯诱导的过氧化物酶体（微体）增殖与肝脏肉碱乙酰转移酶活性增加有关。
Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):501-10.
2
Hepatic microbody proliferation and catalase synthesis induced by methyl clofenapate, a hypolipidemic analog of CPIB.氯苯那酯（CPIB的一种降血脂类似物）诱导的肝脏微体增殖和过氧化氢酶合成。
Am J Pathol. 1974 Apr;75(1):103-18.
3
The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes.降血脂药物（氯贝丁酯、萘酚平、吉非罗齐和Wy-14,643）对肝脏过氧化物酶体及过氧化物酶体相关酶的肝脏效应。
Am J Pathol. 1978 Feb;90(2):435-46.
4
Microbody proliferation in liver induced by nafenopin, a new hypolipidemic drug: comparison with CPIB.新型降血脂药物萘酚平诱导肝脏中微体增殖：与氯苯丁酯的比较。
Biochem Biophys Res Commun. 1973 May 15;52(2):537-43. doi: 10.1016/0006-291x(73)90745-6.
5
Nafenopin-induced hepatic microbody (peroxisome) proliferation and catalase synthesis in rats and mice. Absence of sex difference in response.萘酚平诱导大鼠和小鼠肝脏微体（过氧化物酶体）增殖及过氧化氢酶合成。反应无性别差异。
J Cell Biol. 1974 May;61(2):344-58. doi: 10.1083/jcb.61.2.344.
6
Identification of the hepatic microbody membrane in freeze-fracture replicas.
Lab Invest. 1974 Sep;31(3):268-75.
7
Hepatic catalase is not essential for the hypolipidemic action of peroxisome proliferators.肝脏过氧化氢酶对于过氧化物酶体增殖剂的降血脂作用并非必不可少。
Proc Soc Exp Biol Med. 1977 Apr;154(4):483-7. doi: 10.3181/00379727-154-39699.
8
Possible properties of microbodies (peroxisomes). Microbody proliferation and hypolipidemic drugs.微体（过氧化物酶体）的可能特性。微体增殖与降血脂药物。
J Histochem Cytochem. 1973 Nov;21(11):967-71. doi: 10.1177/21.11.967.
9
Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs.小鼠肝脏过氧化物酶体的肉碱辛酰基转移酶：特性及降血脂药物的作用
Arch Biochem Biophys. 1983 Apr 1;222(1):123-32. doi: 10.1016/0003-9861(83)90509-x.
10
Effect of administration of clofibrate and clofenapate on the content and distribution of ubiquinone in rat tissues.
Indian J Biochem Biophys. 1974 Mar;11(1):51-3.

引用本文的文献

1
Peroxisome Proliferator-Activated Receptors and the Hallmarks of Cancer.过氧化物酶体增殖物激活受体与癌症的特征。
Cells. 2022 Aug 5;11(15):2432. doi: 10.3390/cells11152432.
2
Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation.PPARα基因敲除小鼠的代谢谱分析揭示了肉碱和氨基酸稳态方面的缺陷，口服补充肉碱可部分逆转这些缺陷。
FASEB J. 2009 Feb;23(2):586-604. doi: 10.1096/fj.08-119420. Epub 2008 Oct 22.
3
The effect of feeding Di-(2-ethylhexyl) phthalate (DEHP) on the lipid metabolism of laying hens.
喂食邻苯二甲酸二（2-乙基己基）酯（DEHP）对蛋鸡脂质代谢的影响。
Lipids. 1980 Mar;15(3):151-6. doi: 10.1007/BF02540961.
4
Response of chemically induced hepatocytelike cells in hamster pancreas to methyl clofenapate, a peroxisome proliferator.化学诱导的仓鼠胰腺类肝细胞对过氧化物酶体增殖剂氯苯那酯甲酯的反应。
J Cell Biol. 1982 Oct;95(1):50-6. doi: 10.1083/jcb.95.1.50.
5
Immunochemical identity of peroxisomal enoyl-CoA hydratase with the peroxisome-proliferation-associated 80,000 mol wt polypeptide in rat liver.大鼠肝脏中过氧化物酶体烯酰辅酶A水合酶与过氧化物酶体增殖相关的80,000道尔顿多肽的免疫化学同一性。
J Cell Biol. 1981 Jun;89(3):406-17. doi: 10.1083/jcb.89.3.406.
6
Partial purification and immunoreactivity of an 80 000-molecular-weight polypeptide associated with peroxisome proliferation in rat liver.与大鼠肝脏过氧化物酶体增殖相关的80000分子量多肽的部分纯化及免疫反应性
Biochem J. 1980 Jun 15;188(3):731-40. doi: 10.1042/bj1880731.
7
Specific changes in the protein composition of rat liver in response to the peroxisome proliferators ciprofibrate, Wy-14,643 and di-(2-ethylhexyl)phthalate.大鼠肝脏蛋白质组成对过氧化物酶体增殖剂环丙贝特、Wy-14643和邻苯二甲酸二（2-乙基己基）酯的特异性变化。
Biochem J. 1985 May 1;227(3):767-75. doi: 10.1042/bj2270767.
8
Concentration-dependent inhibition of development of GGT positive foci in rat liver by the environmental contaminant di(2-ethylhexyl) phthalate.环境污染物邻苯二甲酸二（2-乙基己基）酯对大鼠肝脏中γ-谷氨酰转肽酶阳性病灶发展的浓度依赖性抑制作用。
Environ Health Perspect. 1985 May;60:381-5. doi: 10.1289/ehp.8560381.
9
2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria.2-乙基己酸抑制大鼠肝线粒体中的尿素合成并刺激肉碱乙酰转移酶活性。
Arch Toxicol. 1989;63(2):160-1. doi: 10.1007/BF00316441.
10
Effect of clofibrate application on morphology and enzyme content of liver peroxisomes.氯贝丁酯应用对肝脏过氧化物酶体形态和酶含量的影响。
Histochemistry. 1976 Feb 26;46(3):189-96. doi: 10.1007/BF02462782.