Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Institute of Molecular Genetics of National Research Centre, Kurchatov Institute, Ploshchad' Akademika Kurchatova 2, 123182 Moscow, Russia.
Molecules. 2021 Mar 26;26(7):1878. doi: 10.3390/molecules26071878.
Stabilized melanocortin analog peptide ACTH(6-9)PGP (HFRWPGP) possesses a wide range of neuroprotective activities. However, its mechanism of action remains poorly understood. In this paper, we present a study of the proproliferative and cytoprotective activity of the adrenocorticotropic hormone fragment 6-9 (HFRW) linked with the peptide prolyine-glycyl-proline on the SH-SY5Y cells in the model of oxidative stress-related toxicity. The peptide dose-dependently protected cells from HO, -butyl hydroperoxide, and KCN and demonstrated proproliferative activity. The mechanism of its action was the modulation of proliferation-related genes and stimulation of prosurvival -gene-related pathway, as well as a decrease in apoptosis.
稳定的促黑素细胞皮质素类似肽 ACTH(6-9)PGP（HFRWPGP）具有广泛的神经保护活性。然而，其作用机制仍不清楚。在本文中，我们研究了促肾上腺皮质激素片段 6-9（HFRW）与脯氨酸-甘氨酸-脯氨酸肽连接的促有丝分裂和细胞保护活性在与氧化应激相关毒性的 SH-SY5Y 细胞模型中的作用。该肽可剂量依赖性地保护细胞免受 HO、-丁基过氧化物和 KCN 的侵害，并表现出促有丝分裂活性。其作用机制是调节与增殖相关的基因，刺激生存相关基因途径，并减少细胞凋亡。
