Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Bull Exp Biol Med. 2023 Apr;174(6):716-718. doi: 10.1007/s10517-023-05777-3. Epub 2023 May 8.
We evaluated the effect of ACTH-Pro-Gly-Pro (ACTH-PGP) peptide on the serum levels of pro- and anti-inflammatory cytokines in experimental animals under conditions of chronic restraint stress. Stress exposure over 2 weeks led to an increase in the levels of IL-1β, IL-6, and IFNγ in rats. Daily intraperitoneal injection of ACTH-PGP in a dose of 5 μg/kg before stress exposure significantly decreased the levels of IL-6 and IFNγ by 4.8 and 49.3% respectively. Administration of the peptide in a dose of 50 μg/kg decreased the levels of IL-1β and IFNγ by 51.2 and 39.7%, respectively. However, no changes in the cytokine levels were observed after injection of the peptide in a dose of 500 μg/kg. Thus, ACTH-PGP administered in doses of 5 and 50 μg/kg prevented the stress-induced changes in the levels of pro- and inflammatory cytokines.
我们评估了 ACTH-Pro-Gly-Pro（ACTH-PGP）肽对慢性束缚应激条件下实验动物血清中促炎和抗炎细胞因子水平的影响。2 周的应激暴露导致大鼠中 IL-1β、IL-6 和 IFNγ 的水平增加。在应激暴露前每天腹腔注射 5μg/kg 的 ACTH-PGP，可分别使 IL-6 和 IFNγ 的水平降低 48%和 49.3%。肽的剂量为 50μg/kg 时，可使 IL-1β 和 IFNγ 的水平分别降低 51.2%和 39.7%。然而，在注射 500μg/kg 的肽后，细胞因子水平没有变化。因此，5 和 50μg/kg 剂量的 ACTH-PGP 可预防应激引起的促炎和抗炎细胞因子水平的变化。
