Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
Thorac Cancer. 2021 May;12(10):1629-1633. doi: 10.1111/1759-7714.13956. Epub 2021 Apr 3.
Ciliated multinodular papilloma tumor (CMPT), a subtype of proximal bronchiolar adenoma (BA), is a rare mucin-producing papillary tumor arising in the peripheral lung. The nature of CMPT is so far controversial. The hypothesis that CMPT is a precancerous lesion that can lead to mucinous adenocarcinoma requires further research. A 61-year-old man with a ground-glass opacity (GGO) suspected to be lung adenocarcinoma in the right lower lobe of his lung underwent surgical treatment. Postoperative pathology suggested that the patient had mucinous adenocarcinoma caused by cancerization from CMPT. Targeted next-generation sequencing (NGS) was utilized to detect driver mutations in tumor DNA. Among the identified mutated genes, there were regrettably no high frequency mutations. This report describes a case of mucinous adenocarcinoma caused by cancerization from CMPT, indicating that CMPT may be a neoplasm rather than a metaplastic process and provides histological evidence for the hypothesis that CMPT is a precancerous lesion of mucinous adenocarcinoma.
纤毛多发性结节状乳头状瘤肿瘤（Ciliated Multinodular Papilloma Tumor，CMPT），是近端细支气管腺瘤（Bronchiolar Adenoma，BA）的一个亚型，是一种罕见的黏液性乳头状肿瘤，发生于肺外周。CMPT 的性质目前仍存在争议。CMPT 是一种癌前病变，可能导致黏液性腺癌的假说需要进一步研究。一名 61 岁男性，因右下肺磨玻璃密度影（Ground-Glass Opacity，GGO），疑似肺腺癌，接受了手术治疗。术后病理提示患者为 CMPT 癌变所致的黏液性腺癌。对肿瘤 DNA 进行了靶向下一代测序（Next-Generation Sequencing，NGS）以检测驱动基因突变。在鉴定的突变基因中，令人遗憾的是没有高频突变。本报告描述了一例由 CMPT 癌变引起的黏液性腺癌，表明 CMPT 可能是一种肿瘤而非化生过程，为 CMPT 是黏液性腺癌癌前病变的假说提供了组织学证据。
