耳鸣与听力损失的神经解剖体积差异。
Neuroanatomic Volume Differences in Tinnitus and Hearing Loss.
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California, U.S.A.
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, U.S.A.
出版信息
Laryngoscope. 2021 Aug;131(8):1863-1868. doi: 10.1002/lary.29549. Epub 2021 Apr 3.
OBJECTIVES
To investigate neuroanatomic volume differences in tinnitus and hearing loss.
STUDY DESIGN
Cross-sectional.
METHODS
Sixteen regions of interest (ROIs) in adults (43 male, 29 female) were examined using 3Tesla structural magnetic resonance imaging in four cohorts: 1) tinnitus with moderate hearing loss (N = 31), 2) moderate hearing loss only (N = 15), 3) tinnitus with normal hearing (N = 17), and 4) normal hearing only (N = 13). ROI volumes were corrected for brain size, age, and sex variations. Analysis of covariance (ANCOVA) and post hoc Tukey's test were used to isolate the effects of tinnitus and hearing loss on volume differences. Effect sizes were calculated as the fraction of total variance (η ) in ANCOVA models and percent of mean volume difference relative to mean total volume.
RESULTS
The four cohort ANCOVA revealed tinnitus and hearing loss cohorts to have increased volume in the corona radiata (η = 0.192; P = .0018) and decreased volume in the nucleus accumbens (η = 0.252; P < .0001), caudate nucleus (η = 0.188; P = .002), and inferior fronto-occipital fasciculus (η = 0.250; P = .0001). Tinnitus with normal hearing showed decreased volume in the nucleus accumbens (22.0%; P = .001) and inferior fronto-occipital fasciculus (18.1%; P = .002), and hearing loss only showed increased volume in the corona radiata (10.7%; P = .01) and decreased volume in the nucleus accumbens (22.1%; P = .001), caudate nucleus (16.1%; P = .004), and inferior fronto-occipital fasciculus (18.3%; P = .003).
CONCLUSION
Tinnitus and hearing loss have overlapping effects on neurovolumetric alterations, especially impacting the nucleus accumbens and inferior fronto-occipital fasciculus. Neurovolumetric studies on tinnitus or hearing loss can be more complete by accounting for those two clinical dimensions separately and jointly.
LEVEL OF EVIDENCE
3 Laryngoscope, 131:1863-1868, 2021.
目的
研究耳鸣和听力损失患者的神经解剖体积差异。
研究设计
横断面研究。
方法
使用 3Tesla 结构磁共振成像，对 4 个队列中的 16 个感兴趣区域（ROI）进行了成年人（43 名男性，29 名女性）的检查：1）耳鸣伴中度听力损失（N=31）；2）单纯中度听力损失（N=15）；3）耳鸣伴正常听力（N=17）；4）单纯正常听力（N=13）。对 ROI 体积进行了脑容量、年龄和性别变异的校正。采用协方差分析（ANCOVA）和事后 Tukey 检验来分离耳鸣和听力损失对体积差异的影响。效应大小的计算方法为 ANCOVA 模型中总方差的分数（η）和相对于平均总体积的平均体积差异的百分比。
结果
四个队列的 ANCOVA 显示，耳鸣和听力损失组的放射冠体积增加（η=0.192；P=0.0018），伏隔核（η=0.252；P<0.0001）、尾状核（η=0.188；P=0.002）和下额枕额束（η=0.250；P=0.0001）体积减小。伴有正常听力的耳鸣患者的伏隔核（22.0%；P=0.001）和下额枕额束（18.1%；P=0.002）体积减小，而单纯听力损失患者的放射冠体积增加（10.7%；P=0.01），伏隔核（22.1%；P=0.001）、尾状核（16.1%；P=0.004）和下额枕额束（18.3%；P=0.003）体积减小。
结论
耳鸣和听力损失对神经体积变化有重叠影响，尤其是对伏隔核和下额枕额束的影响。通过分别和联合考虑这两个临床维度，可以使对耳鸣或听力损失的神经体积研究更加完整。
证据水平
3 级喉镜，131：1863-1868，2021。
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