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局限性阴茎癌行 glansectomy 和断层皮片移植重建的手术疗效。

Surgical Outcomes of Glansectomy and Split Thickness Skin Graft Reconstruction for Localized Penile Cancer.

机构信息

A.O.U. Città della Salute e della Scienza di Torino, Department of Neurourology, Italy; A.O.U. Città della Salute e della Scienza di Torino - University of Turin, Department of Urology, Turin, Italy.

A.O.U. Città della Salute e della Scienza di Torino - University of Turin, Department of Urology, Turin, Italy.

出版信息

Urology. 2021 Jun;152:195. doi: 10.1016/j.urology.2021.03.022. Epub 2021 Apr 1.

Abstract

INTRODUCTION

The management of localized penile cancer is based on organ-sparing approaches. Our aim is to report surgical outcomes of glansectomy (GS) and split thickness skin graft (STSG) reconstruction in a consecutive series of penile cancers.

PATIENTS AND METHODS

Patients with a localized penile cancer underwent GS and STSG reconstruction in tertiary referral center. Data were extrapolated from a single center prospective database starting from May 2013 to August 2019. Two different techniques are presented in the video abstract: - a standard GS with dissection over the Bucks' fascia. - a salvage GS with dissection under Bucks' fascia.

RESULTS

A total of 34 patients were enrolled. 30 patients underwent a standard GS, whether a salvage GS was performed in the remainders. The apex of corpora cavernosa was transected in 5 cases due to suspicious of local invasion. Median follow-up was 12 (12-41) months. Operative time was 150 (105-180) minutes. Hospital stay was 2 (1-3) days. A modified TODGA compressive dressing and a catheter were applied and left in place for 5 days. After that a saline washing was used for 2 weeks. The incidence of intraoperative complications was minimal (2.9%). Positive surgical margins were detected in 2.9% of cases, requiring a salvage surgery. The incidence of postoperative complications was 29.4%: 11.7% were classified as Grade 1, 8.8% as Grade 2 and 8.8% as Grade 3a according to Clavien-Dindo classification. 1-year recurrence free-survival (RFS) was 88.2%. 1-y cancer-specific (CSS) and overall survival (OS) resulted 91.2% in both cases. Limitations of the study were the retrospective and single centre nature of the study, the lack of comparative group, the limited number of cases and of follow-up.

CONCLUSIONS

GS and STSG reconstruction represents a safe procedure burden by a low incidence of postoperative complications providing a satisfactory cancer control, with a minimal risk of local recurrence.

摘要

简介

局限性阴茎癌的治疗基于保留器官的方法。我们的目的是报告一系列阴茎癌患者行阴茎部分切除术(GS)和断层皮片移植术(STSG)重建的手术结果。

患者和方法

在三级转诊中心,对局部阴茎癌患者行 GS 和 STSG 重建。数据从 2013 年 5 月至 2019 年 8 月从一个单中心前瞻性数据库中提取。视频摘要中介绍了两种不同的技术:- 标准 GS,在 Bucks 筋膜上进行解剖。- 保留下 Bucks 筋膜的挽救性 GS。

结果

共纳入 34 例患者。30 例患者行标准 GS,其余患者行挽救性 GS。由于局部侵犯的可疑,5 例患者切断了阴茎海绵体的尖端。中位随访时间为 12(12-41)个月。手术时间为 150(105-180)分钟。住院时间为 2(1-3)天。应用改良 TODGA 压迫性敷料和导尿管,留置 5 天。之后,用生理盐水冲洗 2 周。术中并发症发生率较低(2.9%)。2.9%的病例检测到切缘阳性,需要挽救性手术。术后并发症发生率为 29.4%:根据 Clavien-Dindo 分类,11.7%为 1 级,8.8%为 2 级,8.8%为 3a 级。1 年无复发生存率(RFS)为 88.2%。1 年癌症特异性(CSS)和总生存率(OS)分别为 91.2%。研究的局限性在于研究的回顾性和单中心性质、缺乏对照组、病例数和随访时间有限。

结论

GS 和 STSG 重建是一种安全的手术,术后并发症发生率低,提供了令人满意的癌症控制效果,局部复发风险极小。

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