Akintonwa A, Gbajumo S A, Mabadeje A F
Department of Pharmacology, College of Medicine, University of Lagos, Nigeria.
Ther Drug Monit. 1988;10(2):147-9. doi: 10.1097/00007691-198802000-00004.
The placental and milk transfer of chloroquine was studied in seven subjects and six subjects, respectively. Seven pregnant women at term were administered chloroquine phosphate (5 mg/kg) i.m. The maternal blood and arterial and venous umbilical cord blood were obtained during delivery. The maternal chloroquine blood levels varied from 0.438 to 1.193 micrograms/ml. The venous cord blood ranged from 0.607 to 0.869, whereas the arterial levels ranged from 0.480 to 0.905 micrograms/ml. Six subjects who were administered chloroquine phosphate (5 mg/kg) postpartum had chloroquine milk levels of 0.192-0.319 micrograms/ml. The milk:blood ratio ranged from 0.268 to 0.462. Chloroquine readily crossed the placenta and was excreted into the breast milk.
分别对7名受试者和6名受试者进行了氯喹胎盘转运和乳汁转运的研究。7名足月孕妇接受了磷酸氯喹（5毫克/千克）肌肉注射。分娩时采集了母体血液以及脐动脉血和脐静脉血。母体氯喹血药浓度在0.438至1.193微克/毫升之间。脐静脉血浓度范围为0.607至0.869，而脐动脉血浓度范围为0.480至0.905微克/毫升。6名产后接受磷酸氯喹（5毫克/千克）的受试者乳汁中氯喹水平为0.192 - 0.319微克/毫升。乳汁与血液的比值范围为0.268至0.462。氯喹很容易穿过胎盘并排泄到母乳中。
