老年抑郁症中10-羟基去甲替林的异构体

Isomers of 10-hydroxynortriptyline in geriatric depression.

作者信息

Young R C, Dhar A K, Kutt H, Alexopoulos G S

机构信息

Department of Psychiatry, New York Hospital-Cornell Medical Center, White Plains 10605.

出版信息

Ther Drug Monit. 1988;10(2):164-7. doi: 10.1097/00007691-198802000-00008.

DOI:10.1097/00007691-198802000-00008

PMID:3381232

Abstract

In geriatric, depressed inpatients treated with nortriptyline (NT), total unconjugated plasma concentrations of the Z isomer of the 10-hydroxylated metabolite (10-OH-NT) were determined simultaneously with concentrations of the E isomer by high-performance liquid chromatography. Z-10-OH-NT concentrations averaged 14% of E-10-OH-NT concentrations.

摘要

在老年期，对接受去甲替林（NT）治疗的住院抑郁症患者，通过高效液相色谱法同时测定了10 - 羟基代谢物（10 - OH - NT）的Z异构体的总非结合血浆浓度和E异构体的浓度。Z - 10 - OH - NT浓度平均为E - 10 - OH - NT浓度的14%。