一种地高辛样免疫反应性物质的初步鉴定。

Tentative identification of a digoxin-like immunoreactive substance.

作者信息

Toseland P A, Oldfield P R, Murphy G M, Lawson A M

机构信息

Department of Clinical Chemistry, Guy's Hospital, London, U.K.

出版信息

Ther Drug Monit. 1988;10(2):168-71. doi: 10.1097/00007691-198802000-00009.

DOI:10.1097/00007691-198802000-00009

PMID:3381233

Abstract

Three independent immunoassays gave significantly different results when digoxin concentrations were measured in plasma samples from a 68-year-old male patient with renal and liver impairment. These differences were used to provide a means of isolating a digoxin-like immunoreactive substance (DLIS) by high-pressure liquid chromatography. Examination of this fraction by fast atom bombardment-mass spectrometry provided data to support the hypothesis that excess bile acids might be the source of the DLIS in our patient which may also explain the DLIS observed in neonates.

摘要

在对一名患有肾和肝功能损害的68岁男性患者的血浆样本进行地高辛浓度检测时，三种独立的免疫分析得出了显著不同的结果。利用这些差异，通过高压液相色谱法提供了一种分离地高辛样免疫反应性物质（DLIS）的方法。通过快速原子轰击质谱法对该馏分进行检测，获得的数据支持了以下假设：过量的胆汁酸可能是该患者DLIS的来源，这也可能解释了在新生儿中观察到的DLIS。