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对从人血浆超滤液中分离出的一种新型地高辛样物质(DLIS-2)的质谱研究。

Mass spectrometry studies of a novel digoxin-like substance (DLIS-2) isolated from human plasma ultrafiltrate.

作者信息

Dasgupta A, Malik S, Ahmad S, Kenny M

出版信息

Biochem Biophys Res Commun. 1988 May 16;152(3):1435-40. doi: 10.1016/s0006-291x(88)80446-7.

DOI:10.1016/s0006-291x(88)80446-7
PMID:2837188
Abstract

Two unique low molecular weight (531) compounds with both digoxin-like immunoreactivity and Na, K-ATPase inhibitory properties have been isolated from human plasma. One of these, digoxin-like substance 2, (DLIS-2), was studied by fast atom bombardment mass spectrometry and collisionally activated dissociation mass spectrometry/mass spectrometry. The fragment patterns were interpreted as being derived from a lysophosphatidyl serine containing a novel 19:4 fatty acid side chain. The molecular formula C25H42O9NP is consistent with these observations.

摘要

从人血浆中分离出两种具有地高辛样免疫反应性和钠钾 - 三磷酸腺苷酶抑制特性的独特低分子量(531)化合物。其中一种地高辛样物质2(DLIS - 2),通过快原子轰击质谱法和碰撞激活解离质谱法/质谱法进行了研究。碎片图谱被解释为源自含有新型19:4脂肪酸侧链的溶血磷脂酰丝氨酸。分子式C25H42O9NP与这些观察结果一致。

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Mass spectrometry studies of a novel digoxin-like substance (DLIS-2) isolated from human plasma ultrafiltrate.对从人血浆超滤液中分离出的一种新型地高辛样物质(DLIS-2)的质谱研究。
Biochem Biophys Res Commun. 1988 May 16;152(3):1435-40. doi: 10.1016/s0006-291x(88)80446-7.
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