采用高效液相色谱法测定癫痫持续状态患者血浆中的劳拉西泮。

Determination of lorazepam in plasma of patients during status epilepticus by high-performance liquid chromatography.

作者信息

Gunawan S, Treiman D M

机构信息

Neurology Service, Veterans Administration West Los Angeles Medical Center, California.

出版信息

Ther Drug Monit. 1988;10(2):172-6. doi: 10.1097/00007691-198802000-00010.

DOI:10.1097/00007691-198802000-00010

PMID:3381234

Abstract

A reversed-phase high-performance liquid chromatography method for the determination of lorazepam in human plasma has been developed. The method was used to analyze plasma samples obtained from patients who were treated with 0.1 mg/kg of intravenous lorazepam during status epilepticus. The detection limit for lorazepam was 5 ng/ml. None of the most commonly used antiepileptic drugs interfere with this lorazepam analysis.

摘要

已开发出一种反相高效液相色谱法用于测定人血浆中的劳拉西泮。该方法用于分析在癫痫持续状态期间接受0.1mg/kg静脉注射劳拉西泮治疗的患者的血浆样本。劳拉西泮的检测限为5ng/ml。最常用的抗癫痫药物均不干扰该劳拉西泮分析。