Sorel L, Mechler L, Harmant J
Clin Ther. 1981;4(4):326-36.
The primary use of lorazepam, when administered intravenously (IV), has been in the treatment of acute attacks of anxiety and agitation. Recent studies have investigated its efficacy in patients with status epilepticus. The present study compared the efficacy and tolerability of lorazepam and clonazepam in the treatment of status epilepticus. Lorazepam, 4 to 10 mg IV, and/or clonazepam, 1 mg IV, was administered in 61 hospitalized epileptic patients. If needed, the dose of each agent was repeated in 20 minutes. Twenty-two patients were given lorazepam, nine were given clonazepam, and 30 were given both drugs at different times. Improvement in EEG was greater with lorazepam while the clinical symptoms responded more completely to clonazepam. Both drugs were most effective in patients with secondary generalized epilepsy. Drowsiness followed either drug. Psychomotor agitation followed either drug in 12% of patients.
静脉注射劳拉西泮的主要用途一直是治疗焦虑和激动的急性发作。最近的研究调查了其在癫痫持续状态患者中的疗效。本研究比较了劳拉西泮和氯硝西泮治疗癫痫持续状态的疗效和耐受性。对61例住院癫痫患者静脉注射4至10毫克劳拉西泮和/或1毫克氯硝西泮。如有需要，每种药物的剂量在20分钟后重复使用。22例患者给予劳拉西泮，9例给予氯硝西泮，30例在不同时间给予两种药物。劳拉西泮使脑电图改善更明显，而临床症状对氯硝西泮反应更完全。两种药物对继发性全身性癫痫患者最有效。两种药物都会导致嗜睡。12%的患者使用任何一种药物后都会出现精神运动性激越。
