Department of Pharmacology, Vanderbilt University, Nashville, TN, 37240-7933, USA.
Department of Pharmacology, Vanderbilt University, Nashville, TN, 37240-7933, USA; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, 37240-7933, USA.
Cell Calcium. 2021 Jun;96:102402. doi: 10.1016/j.ceca.2021.102402. Epub 2021 Mar 26.
Several proteins containing C2 domains have been identified as Ca sensors for neurotransmitter release. In several cases, multiple C2 domain containing proteins function together to sustain evoked synchronous and asynchronous release as well as Ca-dependent forms of spontaneous release. Most recent publication by Li and colleagues have identified a novel Ca sensor at the C. elegans neuromuscular junction [8] that complements the fast Ca sensor synaptotagmin-1 in mediating a slower form of evoked release. Here, we discuss these results as well as earlier work suggesting an evolutionarily conserved diversity of Ca sensors mediating distinct forms of neurotransmitter release.
几种含有 C2 结构域的蛋白质已被鉴定为神经递质释放的 Ca 传感器。在几种情况下，多个含有 C2 结构域的蛋白质共同作用，以维持诱发的同步和异步释放以及 Ca 依赖性的自发性释放形式。最近 Li 及其同事的出版物在秀丽隐杆线虫的神经肌肉接点上鉴定出一种新型的 Ca 传感器[8]，它补充了快速 Ca 传感器突触结合蛋白-1 来介导较慢形式的诱发释放。在这里，我们讨论这些结果以及更早的工作，这些工作表明存在介导不同形式神经递质释放的 Ca 传感器的进化保守多样性。
