结直肠癌患者 STC2 mRNA 表达的临床意义。
Clinical Significance of Stanniocalcin2 mRNA Expression in Patients With Colorectal Cancer.
机构信息
Department of Gastrointestinal Surgery, Kanagawa Cancer Centre, Yokohama, Japan.
Department of Surgery, Yokohama City University, Yokohama, Japan.
出版信息
Anticancer Res. 2021 Apr;41(4):2117-2122. doi: 10.21873/anticanres.14983.
BACKGROUND/AIM: Stanniocalcin2 (STC2) is associated with proliferation, invasion, and metastasis in various cancers. We examined the clinical significance of STC2 mRNA expression in patients with colorectal cancer (CRC).
PATIENTS AND METHODS
Relative expression levels of STC2 mRNA in CRC tissues and corresponding normal mucosa obtained from 202 patients were measured using quantitative real-time reverse transcriptase-polymerase chain reaction.
RESULTS
Expression of STC2 mRNA was higher in the cancer tissue than in the adjacent normal mucosa. STC2 mRNA expression in cancer tissues was associated with tumour size, liver metastasis, venous invasion, and lymph node metastasis. High expression of STC2 mRNA was significantly associated with poorer postoperative survival (p=0.0003). Multivariate analysis showed that high expression of STC2 mRNA was an independent predictor of postoperative survival.
CONCLUSION
High expression of STC2 mRNA in CRC tissue may be a useful prognostic marker in patients with CRC.
背景/目的：Stanniocalcin2（STC2）与多种癌症的增殖、侵袭和转移有关。我们检测了 STC2mRNA 在结直肠癌（CRC）患者中的表达的临床意义。
患者与方法
202 例患者的 CRC 组织及其相应的正常黏膜中 STC2mRNA 的相对表达水平采用实时定量逆转录聚合酶链反应进行测量。
结果
STC2mRNA 在癌组织中的表达高于邻近的正常黏膜。癌组织中 STC2mRNA 的表达与肿瘤大小、肝转移、静脉侵犯和淋巴结转移有关。STC2mRNA 的高表达与术后生存不良显著相关（p=0.0003）。多因素分析显示，STC2mRNA 的高表达是术后生存的独立预测因子。
结论
CRC 组织中 STC2mRNA 的高表达可能是 CRC 患者有用的预后标志物。
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