比较胆道癌患者手术后基于炎症的预后评分。

Comparison of Inflammation-based Prognostic Scores in Patients With Biliary Tract Cancer After Surgical Resection.

机构信息

Department of Surgery, National Hospital Organization Fukuyama Medical Center, Hiroshima, Japan

Department of Surgery, National Hospital Organization Fukuyama Medical Center, Hiroshima, Japan.

出版信息

Anticancer Res. 2021 Apr;41(4):2147-2155. doi: 10.21873/anticanres.14987.

DOI:10.21873/anticanres.14987

PMID:33813426

Abstract

BACKGROUND/AIM: Inflammation-based prognostic scores are proven prognostic biomarkers in various cancers. This study aimed to identify a useful prognostic score for patients with biliary tract cancer (BTC) after surgical resection.

PATIENTS AND METHODS

This retrospective study recruited 115 patients with BTC during 2010-2020. The relationship between clinicopathological variables, including various prognostic scores and overall survival (OS), was investigated using univariate and multivariate analyses.

RESULTS

BTC included 58 cholangiocarcinoma, 29 gallbladder carcinoma, 16 ampullary carcinoma, and 12 perihilar cholangiocarcinoma cases. A significant difference was detected in OS of patients with a Japanese modified Glasgow prognostic score (JmGPS) 0 (n=62) and JmGPS 1 or 2 (high JmGPS) (n=53). In the multivariate analysis, tumour differentiation (p=0.014) and a high JmGPS (p=0.047) were independent prognostic factors.

CONCLUSION

The high JmGPS was an independent prognostic predictor after surgical resection and was superior to other prognostic scores.

摘要

背景/目的：基于炎症的预后评分已被证实是多种癌症的预后生物标志物。本研究旨在确定一种用于胆道癌（BTC）患者手术后的有用预后评分。

患者与方法

本回顾性研究招募了 2010 年至 2020 年期间的 115 名 BTC 患者。使用单因素和多因素分析研究了临床病理变量（包括各种预后评分和总生存期（OS））之间的关系。

结果

BTC 包括 58 例胆管癌、29 例胆囊癌、16 例壶腹癌和 12 例肝门胆管癌。在 OS 方面，日本改良格拉斯哥预后评分（JmGPS）为 0（n=62）和 JmGPS 1 或 2（高 JmGPS）（n=53）的患者存在显著差异。多因素分析显示，肿瘤分化（p=0.014）和高 JmGPS（p=0.047）是独立的预后因素。