Division of Trauma and Orthopaedic Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Arch Orthop Trauma Surg. 2022 Jul;142(7):1547-1556. doi: 10.1007/s00402-021-03873-5. Epub 2021 Apr 3.
This study aimed to investigate potential factors, including delay to surgical stabilisation, affecting mortality in older patients sustaining pelvic or acetabular (PA) fractures.
A retrospective review of the Trauma Audit and Research Network (TARN) database was performed to identify older patients (aged 65 and over) sustaining PA fractures treated surgically in a UK Major Trauma Centre (MTC) between 2015 and 2019. Chi-squared and Fisher tests were used to compare 1-year mortality rates following operative intervention between patients treated within 72 h and after 72 h. Kaplan-Meier curves were used to visualise survival probability; significant predictors of survival were found using Cox proportional hazard models.
Of 564 older patients with PA fractures, 70 met the inclusion criteria. The mean age was 76.1 years. The overall 1-year mortality rate was 20%. When patients were grouped by time to surgery (fracture fixation within or greater than 72 h), there was no statistically significant difference in 1-year mortality. Patients whose surgery was delayed more than 72 h were more likely to have longer hospital stays (p = 0.002) or to have suffered from polytrauma (p = 0.025). Age, Charlson Co-morbidities Index (CCI) and pre-op mobility status were associated with statistically significant differences in overall mortality. The same factors were associated with a significantly increased hazard of death in the multivariate Cox proportional hazards model. Patient gender, mechanism of injury, Injury Severity Score (ISS) > 15 and head injury were not significant predictors of mortality.
Surgical intervention within 72 h of injury did not result in decreased mortality in older patients with PA fractures. The 1-year mortality rate between older PA fractures and hip fractures was comparable. Consideration should be given to a combined multidisciplinary approach between orthogeriatric and expert PA surgeons for these patients.
本研究旨在探讨包括手术稳定延迟在内的潜在因素对老年骨盆或髋臼(PA)骨折患者死亡率的影响。
对创伤审核和研究网络(TARN)数据库进行回顾性分析,以确定 2015 年至 2019 年期间在英国大型创伤中心(MTC)接受手术治疗的老年(65 岁及以上)PA 骨折患者。使用卡方检验和 Fisher 检验比较 72 小时内和 72 小时后手术干预后 1 年死亡率。Kaplan-Meier 曲线用于可视化生存概率;使用 Cox 比例风险模型发现生存的显著预测因素。
564 例 PA 骨折老年患者中,70 例符合纳入标准。平均年龄为 76.1 岁。总的 1 年死亡率为 20%。当患者按手术时间分组(骨折固定在 72 小时内或大于 72 小时)时,1 年死亡率无统计学差异。手术延迟超过 72 小时的患者住院时间更长(p=0.002)或遭受多发伤(p=0.025)的可能性更大。年龄、Charlson 合并症指数(CCI)和术前活动状态与总死亡率有统计学显著差异。同样的因素与多变量 Cox 比例风险模型中死亡风险显著增加相关。患者性别、损伤机制、损伤严重程度评分(ISS)>15 和头部损伤不是死亡率的显著预测因素。
PA 骨折老年患者受伤后 72 小时内进行手术干预并未降低死亡率。老年 PA 骨折与髋部骨折的 1 年死亡率相当。对于这些患者,应考虑骨科老年病学和专家 PA 外科医生之间的联合多学科方法。