大剂量甲氨蝶呤联合亚叶酸钙治疗成人难治性淋巴瘤
High dose methotrexate with citrovorum factor in adult resistant lymphoma.
作者信息
Turman S, Coleman M, Silver R T, Pasmantier M
出版信息
Cancer. 1977 Dec;40(6):2823-8. doi: 10.1002/1097-0142(197712)40:6<2823::aid-cncr2820400612>3.0.co;2-2.
Seven adult patients with advanced lymphoma, resistant to vincristine, prednisone, alkylating agents and Adriamycin were treated with "high dose" methotrexate and citrovorum factor rescue. Therapy consisted of 4 to 6-hour infusions of methotrexate (5--100 mg/kg) every 1 to 2 weeks with citrovorum rescue initiates 2 to 12 hours after termination of the infusion. Objective responses were obtained in three patients but these were short lived. Mucosal and hematologic toxicity occurred when repeat courses of therapy were administered. The results suggest that high dose methotrexate may be effective therapy in lymphoma, particularlly if citrovorum factor rescue is used early and in adequate dosage.
7例晚期淋巴瘤成年患者，对长春新碱、泼尼松、烷化剂和阿霉素耐药，接受了“大剂量”甲氨蝶呤及亚叶酸解救治疗。治疗方案为每1至2周静脉滴注甲氨蝶呤（5 - 100mg/kg）4至6小时，并在滴注结束后2至12小时开始用亚叶酸解救。3例患者获得了客观缓解，但缓解期短暂。再次进行疗程治疗时出现了黏膜和血液学毒性。结果表明，大剂量甲氨蝶呤可能是淋巴瘤的有效治疗方法，特别是早期使用足够剂量亚叶酸解救时。
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