Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, OH, USA.
Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.
J Alzheimers Dis. 2021;81(2):487-492. doi: 10.3233/JAD-201573.
Sleep dysfunction has been identified in the pathophysiology of Alzheimer's disease (AD); however, the role and mechanism of circadian rhythm dysfunction is less well understood. In a well-characterized cohort of patients with AD at the mild cognitive impairment stage (MCI-AD), we identify that circadian rhythm irregularities were accompanied by altered humoral immune responses detected in both the cerebrospinal fluid and plasma as well as alterations of cerebrospinal fluid biomarkers of neurodegeneration. On the other hand, sleep disruption was more so associated with abnormalities in circulating markers of immunity and inflammation and decrements in cognition.
睡眠功能障碍已被确定为阿尔茨海默病（AD）的病理生理学的一部分；然而，昼夜节律功能障碍的作用和机制还不太清楚。在一组轻度认知障碍（MCI-AD）的 AD 患者中，我们发现昼夜节律不规律伴随着体液免疫反应的改变，这种改变在脑脊液和血浆中都有检测到，以及神经退行性变的脑脊液生物标志物的改变。另一方面，睡眠中断与循环免疫和炎症标志物的异常以及认知能力下降的关系更为密切。
