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伴 T 滤泡辅助表型的结外周 T 细胞淋巴瘤在治疗期间表现为舞蹈症：病例报告及文献复习。

Nodal Peripheral T-cell Lymphoma with T Follicular Helper Phenotype Presenting as Chorea During Treatment: A Case Report and Literature Review.

机构信息

Department of Hematology and Oncology, Okayama University Hospital, Japan.

Center for Comprehensive Genomic Medicine, Okayama University Hospital, Japan.

出版信息

Intern Med. 2021 Oct 1;60(19):3155-3160. doi: 10.2169/internalmedicine.7180-21. Epub 2021 Apr 5.

DOI:10.2169/internalmedicine.7180-21
PMID:33814503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8545639/
Abstract

A 72-year-old man presented with chorea while undergoing treatment for recurrence of nodal peripheral T-cell lymphoma with T follicular helper (TFH) phenotype. An examination by brain N-isopropyl-p-iodoamphetamine (I-IMP)-single photon emission computed tomography (SPECT) revealed no abnormalities other than a decreased cerebral blood flow (CBF) in the left striatum. After four courses of salvage chemotherapy, his clinical symptoms and asymmetric cerebral perfusion improved, suggesting that the decreased CBF had caused chorea. The significance of brain SPECT has not been fully clarified in patients with chorea-associated malignant lymphoma, warranting further investigations. Brain SPECT is an alternative approach to identify abnormalities in such patients.

摘要

一位 72 岁男性在接受复发的淋巴结外周 T 细胞淋巴瘤伴滤泡辅助 T 细胞（TFH）表型治疗时出现舞蹈症。脑 N-异丙基-p-碘代安非他命（I-IMP）单光子发射计算机断层扫描（SPECT）检查除左侧纹状体脑血流（CBF）减少外无其他异常。经过四个疗程的挽救性化疗，他的临床症状和不对称性脑灌注改善，提示 CBF 减少引起了舞蹈症。脑 SPECT 在伴发舞蹈症的恶性淋巴瘤患者中的意义尚未完全阐明，需要进一步研究。脑 SPECT 是识别此类患者异常的一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/e650037bc4e4/1349-7235-60-3155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/c3b293ac0fc1/1349-7235-60-3155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/2c5023c473a5/1349-7235-60-3155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/e650037bc4e4/1349-7235-60-3155-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/c3b293ac0fc1/1349-7235-60-3155-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/2c5023c473a5/1349-7235-60-3155-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60c2/8545639/e650037bc4e4/1349-7235-60-3155-g003.jpg

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Can J Neurol Sci. 2019 Jul;46(4):480-481. doi: 10.1017/cjn.2019.38. Epub 2019 May 6.
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Functional neuroimaging and chorea: a systematic review.功能神经影像学与舞蹈症：一项系统综述
J Clin Mov Disord. 2017 Jun 21;4:8. doi: 10.1186/s40734-017-0056-0. eCollection 2017.
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A case of lymphomatosis cerebri mimicking inflammatory diseases.一例酷似炎症性疾病的脑淋巴瘤病病例。
BMC Neurol. 2016 Aug 8;16:128. doi: 10.1186/s12883-016-0655-7.
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